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65 year-old female with Alzheimer’s disease

65 year-old female with Alzheimer’s disease. Lananh Nguyen, M.D. Division of Neuropathology University of Pittsburgh Medical Center. An autopsy was performed. Identify the structures arrow. An autopsy was performed. Identify the structures arrow. Corpus callosum. Caudate, tail. Thalamus.

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65 year-old female with Alzheimer’s disease

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  1. 65 year-old female with Alzheimer’s disease Lananh Nguyen, M.D. Division of Neuropathology University of Pittsburgh Medical Center

  2. An autopsy was performed. Identify the structures arrow.

  3. An autopsy was performed. Identify the structures arrow. Corpus callosum Caudate, tail Thalamus Lateral geniculate nucleus Hippocampus

  4. Note the atrophy in the brain with the Alzheimer’s disease. Severe atrophy Normal library.med.utah.edu

  5. What microscopic pathology is in abundance in Alzheimer’s disease (AD)?

  6. Neuritic plaques Neurofibrillary tangles Amyloid plaques What microscopic pathology is in abundance in Alzheimer’s disease (AD)?

  7. Neuritic plaques Neurofibrillary tangles Amyloid plaques What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features?

  8. Neuritic plaques : Bielchowsky stain Neurofibrillary tangles: Phosphorylated tau stain Amyloid plaques: Beta amyloid stain What stains would you use to evaluate microscopic pathology in Alzheimer’s disease (AD) for these features?

  9. What “body” would you expect to see in the hippocampus of a person with AD • Hirano bodies

  10. Where in the hippocampus can you find these bodies?

  11. Where in the hippocampus can you find these bodies? • CA1 region of the hippocampus CA3 CA2 CA4 CA1 Dentate gyrus

  12. What are the 4 most common genes linked to AD? • Amyloid precursor protein mutation (causative gene) • Presenilin 1 and Presenilin 2 mutations (causative gene) • Apolipoprotein E4 (risk gene)

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