Introduction to FOCUS Degradation Kinetics training course Jos Boesten Alterra

1. Introduction to FOCUS Degradation Kinetics training course Jos Boesten Alterra Wageningen University and Research Centre The Netherlands

2. Outline Introduction to FOCUS Why FOCUS Degration Kinetics ? Working procedure Membership Trainers and training programme

3. Introduction to FOCUS • FOrum for Co-ordination of the USe of pesticide fate models in EU registration • Founded in 1992 (co-operation between Commission and ECPA) • Aim of FOCUS: • Guidance for environmental fate modelling in context of Annex VI of EEC 91/414 (“… estimate, using a suitable calculation model validated at Community level, the concentration…”)

4. time evolution of FOCUS workgroups

5. Current FOCUS workgroups Steering Committee Version Control (permanent) Degradation Kinetics 2005 Landscape & Mitigation 2005 Air 2006 Groundwater 2006

6. Why FOCUS Degradation Kinetics ? • Estimation of parameters for degradation kinetics (including formation of metabolites and water-sediment) in registration procedures not reproducible: • Example • Notifier: submitted scenario calculations with DT50 = 33 days • registration authority: did not agree, concluded DT50 = 43 days, so redo all scenario calculations • Cause: no agreed guidance, so start this workgroup

7. Working procedure FOCUS Deg Kin Workgroup • Aim defined by SC (3 pages): • Detailed description of aim and boundary conditions • Time restriction • Procedure • Consensus within workgroup • Basis for any discussion is science (and pragmatism) • Product: • Guidance document

8. Working procedure FOCUS Deg Kin Workgroup • Participants are scientists • Membership decided by FOCUS Steering Committee • Only money for hotel and travel expenses

9. Working procedure FOCUS Deg Kin Workgroup • Steps: • Workgroup met 10 times in 2 years and produced report • Report to MS for review (2 months) • Few hundred comments • Workgroup: responded and revised report • Training for experts of all MS • Revised document to EFSA (European Food Safety Authority) for independent scientific review (6 months) • JANUARY 2006: opinion available at www.efsa.eu.int • Review to MS and political decision on implementation

10. Membership of FOCUS Degradation Kinetics 8 persons governmental research institutes, universities, regulatory agencies; 7 Member States 4 persons ECPA (2 from Europe and 2 from US) 1 chairman

11. Martin Dust Russell Jones Sylvia Karlsson Ton van der Linden Guy Soulas Oriol Magrans Soria Inge Fomsgaard Jos Boesten Members of FOCUS Degradation Kinetics Claude Beigel Otto Richter Sabine Beulke Jeremy Dyson Karin Aden

12. Trainers Claude Beigel member of FOCUS Deg Kin WG Dieter Schäfer member of ECPA Kinetics Support Group Jeremy Dyson member of FOCUS Deg Kin WG Jos Boesten chair of FOCUS Deg Kin WG Ralph Warren member of ECPA Kinetics Support Group Russel Jones secretary of FOCUS Deg Kin WG Sabine Beulke member of FOCUS Deg Kin WG

13. Training programme 8:40-8:50 a.m. Introduction Jos Boesten 8:50-9:00 a.m. Remit of work group Russell Jones 9:00-9:15 a.m. Kinetic models considered Jeremy Dyson 9:15-9:30 a.m. Optimization and statistical measures Sabine Beulke 9:30-9:45 a.m. Introduction to Kinetics Software Tool Dieter Schäfer 9:45-10:00 a.m. Break

14. Training programme 10:00-11:30 a.m. Data Handling Issues with hands-on session Sabine Beulke 11:30-12:00 a.m. Non-equilibrium Sorption Jos Boesten 12:00-12:50 p.m. Lunch 12:50-2:15 p.m. Parent kinetics and hands-on session Ralph Warren 2:15-3:45 p.m. Metabolites: theory and hands-on session Claude Beigel 3:45-4:15 p.m. Modelmaker Demonstration Claude Beigel

15. Disclaimer on KinGUI software Workgroup uses software because it is easiest to use for this training Workgroup reviewed a range of software packages: no ‘ideal’ package available Use of this software in training does not imply that other software would not be suitable