230 likes | 563 Views
YAWS. PIAN BUBAS FRAMBOESIA. Yaws and its relatives are caused by spirochete bacteria. Treponema. Contagious , non venereal treponemal infection. No cardiovascular or neurological abnormalities. Yaws is typically found in tropical areas of Africa, South America, and Asia.
E N D
YAWS PIAN BUBAS FRAMBOESIA
Yaws and its relativesare caused by spirochete bacteria Treponema
Contagious , non venereal treponemal infection. • No cardiovascular or neurological abnormalities
Yaws is typically found in tropical areas of Africa, South America, and Asia
Between 1950 and 1970, WHO and UNICEF led a campaign to treat people in 46 countries
Caused by Treponema pertenue . • Reservoir of infection – Man • Age - It affect children < 15 years [peak incidence 6-10 years]. • Immunity – no natural immunity. Provides partial immunity to veneral syphilis.
ENVIRONMENTAL FACTORS • Climate – endemic in warm and humid conditions • Social factors • scanty clothing • Poor personal cleanliness • Overcrowding • Bad housing • Low standard of living • Absence of soap
MODE OF TRANSMISSION • Direct contact • Fomites • Vector INCUBATION PERIOD 3 to 5 weeks
The endemic treponematoses are mainly transmitted by human-to-human contact
CLASSIFICATION • Primary stage …..lesion at site of inoculation. • Secondary stage ….multiple skin lesion. • Latent stage …..no symptom but skin lesion can relapse. • Tertiary ….bone , joint & soft tissue deformality
OTHER CASSIFICATION • Early----: primary & secondary { contagious skin lesion }. • Late -----: tertiary (not contagious).
CLINICAL PRESENTATION • Primary lesion called….. mother yaw.[IP 9-90 days]. • 1ry papule---enlarge → papilloma {resolve spontaneously after 3-6 months }. • 2ry may occur near the 1ry or elsewhere on the body {last for more than 6 months } • Macule , papules , nodules ,and hyperkeratotic lesion in palms & soles { CRAB YAWS } ,lesions may ulcerate. • Saber shin due to chronic untreated osteoperiostitis. • Pt with late yaws → juxtaarticular nodules → gangosa [ rhinopharyngitis mutilans ]
The first sign of yaws is a primary lesion known as a “mother yaw”
After years without treatment, larger problems may develop Saber shin / tibia Gangosa
INVESTIGATIONS • Diagnosis on clinical findings. • Non treponema test:VDRL. Positive in all stages except early lesions . • Dark-field examination ….. + ve . • Biopsy.
These diseases can be diagnosed in two ways Dark field microscopy Serological Tests
MANAGEMENT • Benzathine penicillin ( penicillin G ) 1.2 million units IM once • Penicillin V for 7-10 days.[ for 1ry , 2ry &latent]. • Tetracyclin 1-2 g\ day for 7-14 days.[tertiary] • Erythromycin [tertiary]. • Doxycycline 200mg 1 st ,100 mg\day for 7-14 days.[tertiary].
Benzathine penicillin is the main drug of choice for treatment
CONTROL 1. Survey 2. Treatment • Total mass treatment ( more than 10% prevalence) • Juvenile mass treatment ( 5% to 10 %) • selective mass treatment (less than 5 %) 3. Resurvey and treatment ( every 6 to 12 months) 4. Surveillance 5. Environmental improvement 6. Resurgence of yaws 7. Evaluation