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Modeling and Synthetic Biology

Modeling and Synthetic Biology. DAY THREE: PART ONE. What is a model?. Model. -Concrete -Descriptive -Abstract. Why build a model. Why Model?. -Reveals relationships which were not previously apparent -Not possible to make a physical measurement -Large volume of data

cameron-boyer
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Modeling and Synthetic Biology

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  1. Modeling and Synthetic Biology DAY THREE: PART ONE

  2. What is a model?

  3. Model -Concrete -Descriptive -Abstract

  4. Why build a model

  5. Why Model? -Reveals relationships which were not previously apparent -Not possible to make a physical measurement -Large volume of data -Infeasible experiments -save cost/time

  6. Criticism

  7. Model • ‘Of course your model predicted what you wanted to - you built it’ • ‘I could have figured it out without your model just by doing a simple experiment’

  8. Types of models 1.  Rule-based models 2.  Mass action kinetics 3.  Stoichiometric matrix

  9. In class excercise

  10. Model : Steps for Building 1.Graphical depiction 2.System definition (boundaries & assumptions) & data collection 3. Mathematical expressions 4. System analysis 5. Model curation - ‘I could have figured it out without your model just by doing a simple experiment’

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