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Synthetic Biology

Information in Biology. Synthetic Biology. Mati Cohen. Outline. What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter” . Outline. What is synthetic biology? Biological Clocks The “Repressilator” Signal transduction The “Diverter” .

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Synthetic Biology

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  1. Information in Biology Synthetic Biology Mati Cohen

  2. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  3. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  4. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  5. What is synthetic biology? • The design and construction of new biological parts, devices, and systems • The “Repressilator” • The re-design of existing, natural biological systems for useful purposes. • The “Diverter”

  6. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  7. Biological - Clocks • Three questions • How does it work • How does it synchronize • How does it translate to activity

  8. Biological - Clocks

  9. Biological - Clocks

  10. Biological - Clocks

  11. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  12. The “Repressilator” Movie

  13. Repressilator • oscillations are favored by • Strong promoters • Efficient ribosome-binding sites • Tight transcriptional repression • Comparable protein and mRNA decay rates

  14. Repressilator

  15. Repressilator

  16. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  17. Signal Transduction Movie

  18. The Yeast system • Scaffold proteins • Mediating recruitment • Improve efficiency of signal transfer. • Facilitate interactions among different signal pathways • Control localization of signal proteins within a cell.

  19. Outline • What is synthetic biology? • Biological Clocks • The “Repressilator” • Signal transduction • The “Diverter”

  20. The Pre-Diverter

  21. The Diverter

  22. Diverter results

  23. Diverter results

  24. Summary What is synthetic biology? • The design and construction of new biological parts, devices, and systems The Repressilator • The re-design of existing, natural biological systems for useful purposes. The Diverter

  25. Signal transduction movies signal transduction • http://www.youtube.com/watch?v=tMMrTRnFdI4 signal transduction • http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/signals.htm#animat2

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