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Kaposi’s Sarcoma

Kaposi’s Sarcoma. By: Cody Hull Period 3 Biology March 2, 2005. Part of the Body Affected. Lesions appear: Under the surface of the skin. On mucous membranes. May also be found in internal organs. Particularly the respiratory system or gastrointestinal system. Signs. Lesions appear.

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Kaposi’s Sarcoma

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  1. Kaposi’s Sarcoma By: Cody Hull Period 3 Biology March 2, 2005 I did not lie, cheat, or steal to complete this work.

  2. Part of the Body Affected • Lesions appear: • Under the surface of the skin. • On mucous membranes. • May also be found in internal organs. • Particularly the respiratory system or gastrointestinal system.

  3. Signs • Lesions appear. • May be red, purple, brown, or black. • Can be found on: • The skin • Mucous Membranes • Sometimes in Internal Organs

  4. Symptoms • Having AIDS • Skin or mucous membrane lesions. • Not often fatal. • Unless: • Cause enough swelling to obstruct circulation or breathing. • Lesions in the mouth prevent eating. • Lesions affecting internal organs • Can cause bleeding which is more often fatal. • Prevented by: • Safe sex • Abstinence

  5. How is it Diagnosed? • Suspected by appearance of lesions and risk factors. • Definite diagnosis can only be made by: • Biopsy and microscopic examination. • Shows the presence of spindle cells. • Detection of viral protein LANA in tumor cells confirms the diagnosis.

  6. Treatment • No known cure • Treatment is focused on destroying present lesions. • By: • Chemotherapy drugs (paclitaxel and bleomycin) • Radiation therapy • Surgical removal

  7. Incidence of the cancer Worldwide • In Africa KS has become most frequently reported cancer in some countries • Such as Zimbabwe. • During early years of AIDS epidemic incidence of KS almost exclusively among male homosexuals. • In North America and Europe

  8. Current clinical trials for new Treatments • New Angiogenesis inhibitors • A.K.A. Drugs that block development of blood vessels in tumors. • Blood vessels main component of KS lesions. • New combinations of current chemotherapy drugs • New ways of delivering chemotherapy • encapsulation in fat globules called liposomes • Most effective: • Research into treatment of AIDS and HIV.

  9. Citations: • Wikipedia. The Kaposi’s sarcoma page. Available at: http://en.wikipedia.org/wiki/Kaposi_sarcoma. Accessed Thursday, March 03, 2005. • Explains causes, history, symptoms, treatment, diagnosis, defined scientific terms, and describes relation to AIDS. • Cancerbacup. Kaposi’s sarcoma research-clinical trials. Available at: http://www.cancerbacup.org.uk/Cancertype/Kaposissarcoma/Clinicaltrials/Research-clinicaltrials. Accessed Thursday, March 03, 2005. • Explains current research. • America Cancer Society. What's New in Kaposi Sarcoma Research and Treatment? Available at: http://www.cancer.org/docroot/cri/content/cri_2_4_6x_whats_new_in_kaposis_sarcoma_research_and_treatment_21.asp?sitearea=cri. • Explains current research. • National Cancer Institute. The Kaposi’s sarcoma page. Available at: http://cancerweb.ncl.ac.uk/cancernet/101271.html. Accessed Thursday, March 03, 2005. • Explains causes, history, symptoms, treatment, diagnosis, the different types, and relation to AIDS.

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