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Aldosterone Function and Regulation in Adrenal Gland

Explore the role of aldosterone in Na+/water reabsorption and K+ excretion, mechanisms of action, clinical implications of excess or deficiency, and regulation by factors like potassium ion concentration and angiotensin 2. Understand the complexities of cortisol and its regulation through ACTH for maintaining physiological balance.

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Aldosterone Function and Regulation in Adrenal Gland

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  1. The Adrenal Gland

  2. Anatomy:

  3. Histology:

  4. Aldosterone • Principle: stimulates Na+/water reabsorbtion K+ excretion Lumen cells

  5. Site of action: sweat glands intestines Salivary glands Kidney

  6. Aldosterone

  7. Cellular mechanism Aldosterone diffuses readily to the interior of the cellaldosterone binds its receptorAldosterone receptor complex diffuses into the nucleus and stimulate DNA transcription to mRNAmRNA diffuses back to the cytoplasm where it is translated to proteins.

  8. The protein formed are 2 types: • Enzymes: Na+_K+ ATPase which serves as the principle part of the pump for sodium and potassium exchange. • Membrane transport proteins: epithelial sodium channel (ENaC) which allows rapid diffusion of sodium into the cell from the lumen.

  9. ALDOSTERONE EXCESS • HYPERTENSION • ALKALOSIS • MUSCLE WEAKNESS

  10. Aldosterone Blood flow Filtration

  11. Aldosterone ESCAPES WITH HYPERTENSION!!!

  12. Aldosterone • Principle: stimulates Na+/water reabsorbtion K+/ H+ excretion (ALKALOSOS)!!! Lumen cells K K K K H+ K H+ K K H+ H+

  13. MUSCLE WEAKNESS = MEMBRANE EXCITABILITY DECREASES

  14. ALDOSTERONE EXCESS • HYPERTENSION • ALKALOSIS • MUSCLE WEAKNESS

  15. Aldosterone Deficiency: • Acidosis • Cardiac shock • Hypotension

  16. Aldosterone regulation • Potassium ion concentration • Angiotensin 2 concentration, for example: Angiotensin 2 is secreted in response to diminished blood flow to the kidneys or to sodium loss. Angiotensin2 is secreted in response to renin which is secreted by the kidney. • Sodium concentration, increased sodium concentration in the extra cellular fluid slightly decreases aldosterone secretion. • ACTH is necessary for aldosterone secretion but has a slight role in the amount secreted

  17. Sweat gland/ salivary gland/ intestines To prevent water and salt loss!!

  18. CortisolMineralocorticoids • Cortisone Mineralocorticoid

  19. CORTISOL & carbohydrates

  20. CORTISOL & proteins Body except the liver the liver

  21. Cortisol and fat • Lipolysis ,,,,,BUT:

  22. CORTISOL & stress

  23. Regulation of cortisol secretion: • Cortisol secretion is regulated by adrenocortico tropic hormone ( ACTH) • ACTH secretion is regulated by: • corticotrophin releasing factor (CRF) from the hypothalamus. CRF is highly secreted in response to physiological stimuli. • Cortisol by negative feedback mechanism. so excess cortisol has inhibitory effect on the hypothalamus( decrease CRF secretion) and the anterior pituitary (decrease ACTH secretion) • ADH

  24. ANDROGENS • Zona reticularis produces ANDROGENS + LITTLE AMOUNT OF ESTROGENS. • Regulated by ACTH

  25. CLINICAL PROBLEMS:

  26. CLINICAL PROBLEMS:

  27. Adrenogenital Syndrome: • Caused by an Adrenocortical tumor which secretes high amounts of androgens.

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