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Fluid flow and species transport around a scaffold

Centro Interdipartimentale di Fluidodinamica e Idraulica University of Udine - Italy. Fluid flow and species transport around a scaffold. F. Beux, M. Campolo, A. Soldati. Centro Interdipartimentale di Fluidodinamica e Idraulica & Department of Energy & Technology, University of Udine, Italy.

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Fluid flow and species transport around a scaffold

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  1. Centro Interdipartimentale di Fluidodinamica e Idraulica University of Udine - Italy Fluid flow and species transport around a scaffold F. Beux, M. Campolo, A. Soldati Centro Interdipartimentale di Fluidodinamica e Idraulica & Department of Energy & Technology, University of Udine, Italy Prepared for VIVABIOCELL

  2. Problem • The flow field controls: • Conditions for cell adhesion and growth • Transport of nutrients Φ=4 mm 6 mm 6 mm Water 34 mm Q=4 cm3/min Re=21

  3. Objects • A. Evaluate the flow conditions inside the bioreactor to: • Establish the actual throughput • Verify the flow homogeneity (possibility to feed nutrients/remove catabolites, presence of dead regions) • Quantify the shear distribution (relevant for cellular growth) • B. Identify possible design modification to improve performances

  4. Computational domain > 10 FV ¼ overall domain About 450.000 FV

  5. 1. Results: pressure drop & power ∆p=160 Pa P=10-5 W Maximum pressure drop in small connecting pipes (increase diameter if P is too high)

  6. 2. Results: flow field homogeneity (in-out)

  7. 2. Results: flow field homogeneity (corner)

  8. 2. Results: velocity in volume Maximum velocity in small connecting pipes Minimum velocity in the flow diffuser

  9. 3. Results: shear stress @ scaffold wall p=8e-5÷0.03 Pa

  10. 3. Results: shear stress statistics

  11. Average shear stress variation along scaffold

  12. Concluding remarks • In-Out pressure drop depends on number and diameter of connecting pipes • Flow homogeneity con be improved by changing the angular position of inlet/outlet connecting pipes (45°) • Possibility to evaluate transport (and reaction) of species

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