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T cell Leukemia

T cell Lymphoblastic Lymphoma/Leukemia. CharacteristicsPatients tend to be young adults/adolescents50-80% present with mediastinal mass (pre B -rarely)Peripheral blood involvement >30% at presentationRapidly progressive w/ dissemination to BM

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T cell Leukemia

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    1. T cell Leukemia/Lymphoma T cell Lymphoblastic Lymphoma/Leukemia Post Thymic Leukemias/Lymphomas Prolvmphocytic leukemia/ T cell CLL Adult T cell leukemia/lymphoma Cutaneous T-cell leukemia/lymphoma Sezary Syndrome Mycosis Fungoides Peripheral T cell lymphoma Large granular lymphocytic (LGL)

    2. T cell Lymphoblastic Lymphoma/Leukemia Characteristics Patients tend to be young adults/adolescents 50-80% present with mediastinal mass (pre B -rarely) Peripheral blood involvement >30% at presentation Rapidly progressive w/ dissemination to BM & CSF. Poor prognosis Flow cytometry - excellent - since immature T cell phenotype (while a normal cellular phenotype) is not expected in the sample most commonly submitted (LN, PBL, CSF, pleural fluid). Difficult if thymus is specimen.

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