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New tissue acquisition tools for gene expression analysis

New tissue acquisition tools for gene expression analysis. Tissue quality and patient comfort. Prof. Jaak Ph. Janssens MD, PhD. Translational Research. Molecular biology research PCR, microchips, Proteomics, genomics,… Mutation research, polymorphisms Screening Risk biomarkers

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New tissue acquisition tools for gene expression analysis

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  1. New tissue acquisition tools for gene expression analysis Tissue quality and patient comfort Prof. Jaak Ph. Janssens MD, PhD

  2. Translational Research • Molecular biology research • PCR, microchips, • Proteomics, genomics,… • Mutation research, polymorphisms • Screening • Risk biomarkers • Diagnosis • Fine tuning and reclassification • Personalized therapy • Prognostic markers • Pathway analysis – response prediction

  3. Obstacles for translational research

  4. Obstacles for translational research

  5. Requirements for tissue acquistion related to translational research • Tissue quality • Representative • One large piece of tissue • No artifacts • Patient comfort • No pain, no complication risk = safe • Inexpensive • Access • Handsome • Fast – minimal personnel • No dedicated room

  6. Tissue acquisition quality problem

  7. Fine needle aspiration (Cytology) • Microbiopsy (16 to 14 Gauge) • Macrobiopsy (8 to 12 Gauge) • Open biopsy (general anaesthesia)

  8. Results from safety and efficacy trials (n = 300 patients)

  9. Tissue acquisition for translational research

  10. Medinvents’ Products • A range of large core soft tissue biopsy needles • Based on NEW double rota-cutting technique • 8 – 14 Gauge • Vacuum system on Single Use • Product portfolio: • Spirotome Single Use/Reusable • Spirotome Cervicore ™ • Spirotome MRI ™ • Spirotome Bone ™ • Spirotome Easy Punch ™ • Automated version • Handheld or stereotactically positioned • Reusable handle controller, disposable • 8 – 10 Gauge needles • Vacuum assisted system • Multiple samples without reinserting

  11. Medinvents’ Applications • Spirotome™ • Breast • Thyroid • Salivary glands • Thoracic wall • Abdominal wall • Lymph nodes • Muscle • Liver • Coramate ™ • Breast • Thyroid • Salivary glands • Thoracic wall • Abdominal wall • Lymph nodes • Muscle • Spirotome Cervicore ™ • Cervix • Uterus • Spirotome Bone ™ • Soft tissues within bone • Spirotome Easy Punch ™ • Skin • Vulva

  12. Conclusion

  13. Clinical Study & Advisory Group Thank you.

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