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Acetaminophen

Acetaminophen. 10–20% opioid-sparing effect 1 Synergistic with oral opioids 2 Additive effect greater than NSAIDs alone 3 IV preparation: Quick onset 4 Good side-effect profile; RID: 1–2%. 1. Remy, Br J Anaesth 2005;94:505–13 2. Chandrasekharan, Proc Natl Acad Sci 2002;99:13926–31

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Acetaminophen

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  1. Acetaminophen 10–20% opioid-sparing effect1 Synergistic with oral opioids2 Additive effect greater than NSAIDs alone3 IV preparation: Quick onset4 Good side-effect profile; RID: 1–2% 1. Remy, Br J Anaesth2005;94:505–13 2. Chandrasekharan, Proc Natl Acad Sci 2002;99:13926–31 3. Ong, Anesth Analg2010;110:1170–9 4. Alhashemi, Can J Anaesth2006;53:1200–6 RID, relative infant dose

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