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Proliferation of CLL Cells After Adoptive Transfer

Proliferation of CLL Cells After Adoptive Transfer. BAFF Promotes CLL Cell Survival. Without BAFF. + BAFF. BCMA-Fc. Anti-BAFF-R. Endo, T, et al. Blood 109 :703-710, 2007. Inhibitors of Nurse-like Cells. Anti-BAFF-R BCMA-Ig. NF-kB Inhibitor IKK-beta Antagonists.

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Proliferation of CLL Cells After Adoptive Transfer

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  1. Proliferation of CLL Cells After Adoptive Transfer

  2. BAFF Promotes CLL Cell Survival Without BAFF + BAFF

  3. BCMA-Fc Anti-BAFF-R Endo, T, et al. Blood 109:703-710, 2007

  4. Inhibitors of Nurse-like Cells Anti-BAFF-R BCMA-Ig NF-kB Inhibitor IKK-beta Antagonists

  5. Ad-CD154 CLL Gene Therapy of CLL Administration of Transduced Cells Cell Collection Incubation QA/QC Cell Transduction

  6. IgG 1600 #1 1400 #2 1200 Normal Levels (mg/dL) IgG = 791-1643 IgA = 66 - 436 IgM = 43 - 279 1000 #3 IgG (mg/dL) 800 #4 600 #5 400 #6 200 0 PRE POST IgA IgM 200 160 180 140 160 120 140 100 120 IgA (mg/dL) IgM (mg/dL) 100 80 80 60 60 40 40 20 20 0 0 PRE POST PRE POST Total Serum Ig Levels of CLL Patients Before and After Ad-CD154 Treatment

  7. #1 #2 #3 #4 #5 #6 Anti-adenovirus Antibodies of CLL Patients Before and After Ad-CD154 Treatment

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