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Measurement of Electrical Signals in the Intestine

Measurement of Electrical Signals in the Intestine. Allison Redmond and Kevin Parton Advised by: Dr. Bill Richards, M.D. Dr. Alan Bradshaw, Ph.D. Dr. Scott Seidel, M.D. Overview of Physiology. Consists of ileum, jejunum, and duodenum Composed of smooth muscle Involuntary response

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Measurement of Electrical Signals in the Intestine

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  1. Measurement of Electrical Signals in the Intestine Allison Redmond and Kevin Parton Advised by: Dr. Bill Richards, M.D. Dr. Alan Bradshaw, Ph.D. Dr. Scott Seidel, M.D.

  2. Overview of Physiology • Consists of ileum, jejunum, and duodenum • Composed of smooth muscle • Involuntary response • Important to body’s uptake of nutrients and removal of wastes

  3. Electrical Signals in the Intestine? • All muscle conducts electrical impulses to be active • Manifested as BER • Basic Electrical Rhythm • 10-12 cycles per minute • This electrical activity can be measured

  4. Problem • Intestine can be ischemic • Lack of blood flow • leads to necrosis • Necrotic bowel must be removed • surrounded by “gray areas” • need to check periodically • Causes need for additional surgery

  5. Group Purpose • Electrodes can be introduced • attached to recording equipment • Values can be taken • propagation velocity • amplitude • frequency • Can be diagnostic • extra surgeries not necessary

  6. Our Objective • Tissue Impedance can be measured • Done on surface and in body • Known values not available • Impedance should change with necrosis • We will test in rabbits • Our hope is that this will lead to better assessment of overall function

  7. Past Work • Determine best method for investigating tissue impedance. • Learn to use LR-700 AC Resistance Bridge. • Call Linear Research Inc. for technical assistance.

  8. Current Work • Design connection from impedance meter to electrodes • Gather materials • Begin assembly • Test meter accuracy on sciatic nerve of frog

  9. Future Work • Test electrodes on a rabbit to determine the correct configuration. • Using our connector device, test bowel impedance of a rabbit during ischemia. • If there is significant change, begin construction of a medically suitable impedance meter.

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