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Drug Use, Misuse and Residues

Drug Use, Misuse and Residues. Dr. Simon Kenyon. Drug Use in Food Animals. OTC, Prescription, ELUD For ELUD Valid veterinarian/client/patient relationship (VCPR) No labeled drug alternative available Adequate records are kept by veterinarian and client

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Drug Use, Misuse and Residues

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  1. Drug Use, Misuse and Residues Dr. Simon Kenyon

  2. Drug Use in Food Animals • OTC, Prescription, ELUD • For ELUD • Valid veterinarian/client/patient relationship (VCPR) • No labeled drug alternative available • Adequate records are kept by veterinarian and client • Significantly prolonged withdrawal times • Properly labeled by veterinarian • No extra-label privilege for feed additives

  3. Milk and Dairy Beef Residue Prevention Protocol • Practice Healthy Herd Management • Establish a Valid VCPR • Use Only FDA Approved OTC or Prescription Drugs • Label Correctly • Store Drugs Correctly • Administer Drugs Correctly and Identify Treated Animals • Maintain Treatment Records • Use Drug Residue Screening Tests • Implement Employee/Family Awareness • Complete Protocol Annually

  4. The Market for Swine Drugs • Growth promotants ( e.g.lincomycin, tylosin, virginiamycin) • GI Disease, particularly nursery pigs • Respiratory Disease, (tetracyclines, Pulmotil) • Ileitis (tylosin, lincomycin) • Atrophic Rhinitis • External and Internal Parasites

  5. What Drives the Market for Cattle Drugs? • Respiratory Disease • Parasitism • Reproduction • Mastitis • Production enhancement • BST • Bovatec/Rumensin

  6. Special features of the dairy cow • Product sold daily • Intense product surveillance and regulation • Milk contains fat • Special health issues of milking cows • Metabolic disease • Mastitis • Reproductive (infectious and hormonal) • Infectious foot conditions

  7. Potential risks to humans from drug residues • Direct poisoning by drug residue • Toxicity • Pharmacologic effect • Cancer • Mutations • Change gut bacteria • Bacterial drug resistance • Allergy • Effects on food processing

  8. Illegal Drugs • Drugs banned from use in dairy animals • Sulfamethazine (except under 20 months) • Other sulfonamides (esp. sustained release products) • Tetracyclines as feed additives • But now labeled for dairy as therapeutic drug eg LA-200

  9. Illegal drugs • Banned in any food animal • Chloramphenicol • Clenbuterol (Ventipulmin) • Diethylstilbestrol (DES) & estradiol • Dimetridazole • Ipronidazole • Other nitroimidazoles (e.g. metronidazole (Flagyl))

  10. Illegal drugs • Banned in any food animal • Furazolidone • Nitrofurazone • Fluoroquinolones (e.g. Baytril, A180) except approved use • Glycopeptides (e.g. Vancomycin) • Dipyrone (Metamizole) • Phenylbutazone (dairy >20mths)

  11. Concerns over Antibiotic Use • Fluoroquinolones • Naxcel and Excenel • Cefazolin • Gentamicin (Gentocin) • On farm decision-making • Injectables vs intramammary for mastitis treatment • Extended antibiotic therapy for mastitis • Multiple use bottles for intramammary • Medicated milk replacer – veal - neomycin

  12. Other drug issues • European ban on hormonal growth promotants (Precautionary Principle) • Estradiol, progesterone, testosterone • Trenbolone, zeranol (Ralgro), melengestrol acetate • Minor Use, Minor Species Act, 2004 (MUMS) (e.g.repro. drugs for sheep) • conditional approval, • index of legal marketed unapproved animal drugs • orphan drugs

  13. Useful references • Pork Quality Assurance • www.porkboard.org • Milk and Dairy Beef Residue Prevention • www.DQAcenter.org • FDA Center for Veterinary Medicine • www.fda.gov/cvm/ • Drug Residues in Foods, Botsoglou NA, Fletouris DJ, Marcel Dekker 2001 615.594 B658d 2001

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