1 / 1

Small Animal Cone beam CT Class project for 600.446, Advanced Computer-Integrated Surgery, Spring 2006

X-Ray Tube. Camera Box. Small Animal Cone beam CT Class project for 600.446, Advanced Computer-Integrated Surgery, Spring 2006. SYSTEM OVERVIEW The small animal cone beam CT (SACBCT) system is a component of a prototype image guided small animal radiation therapy research platform.

cerise
Download Presentation

Small Animal Cone beam CT Class project for 600.446, Advanced Computer-Integrated Surgery, Spring 2006

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. X-Ray Tube Camera Box Small Animal Cone beam CTClass project for 600.446, Advanced Computer-Integrated Surgery, Spring 2006 SYSTEM OVERVIEW The small animal cone beam CT (SACBCT) system is a component of a prototype image guided small animal radiation therapy research platform. When completed, the system will provide a means of testing novel image guided radiation therapy techniques on standard laboratory oncological models (OncoMouse etc.) to characterize dose response of tumors in a preclinical laboratory setting. (a) (b) (c) Figure 1: (a) Helical CT scan. (b) Cone beam CT for human (c) the system for the small animal cone beam CT THE PROBLEM • Prototype hardware platform for acquiring the SACBCT images completed • However, there is no software for image correction, dewarping and reconstruction for novel small-animal cone beam CT system THE SOLUTION Build Java software to simplify the operation of the platform • Image intensity correction • Characterize variation in X-ray attenuation • Reconstruction of 2D projection images into volumetric representation using the Feldkamp algorithm • Output volumetric rendering in standard DICOM format for future use. • UI for display and manipulation of 2D and 3D images: Figure 2: Experimental lab set up THE FUTURE • On-line, near real-time data acquisition and processing • Integrated calibration routines • Conversion to flat-panel detector with mechanical shutter from direct-imaged phosphor system • In-situ imaging and image-guided conformal beam therapy Figure 3: Screen Shots PEOPLE INVOLVED • Mentors: Dr. John Wong, PhD, Dr. Todd McNutt, PhD and Dr. Eric Ford, PhD (Department of Radiology oncology) • Team Members: Owen Gray, Sungjun Kim and Pinak Pujari (Computer Science graduate students) THE IMPACT • Currently, experimental image guided radiotherapy and conformal beam therapy techniques are performed on human subjects • The small animal radiotherapy research platform (SARRP) allows novel techniques to be validated and studied on the standard animal oncological models (Harvard OncoMouse and similar) in a convenient bench top environment • This research is expected to speed the availability of novel therapies, and provide rigorous validation of procedures in pre-clinical trials LESSONS LEARNED • Working in group is not easy. (schedule conflict and different technical background.) • Satisfying customer’s needs not like just doing homework assignments. SUPPORTED BY: • NIH R01 project (Principle investigator Dr. John Wong, Rad. Onc., JHMI), Engineering Research Center for Computer Integrated Surgical Systems and Technology

More Related