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Antibody responses and pathology in TB

Antibody responses and pathology in TB. Quantitative and qualitative variation between infected individuals and differences between host species: Elephant >> Wild boar > Deer > Bison > Cattle > Camelids >>> Badger > Possum

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Antibody responses and pathology in TB

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  1. Antibody responses and pathology in TB • Quantitative and qualitative variation between infected individuals and differences between host species: Elephant >> Wild boar > Deer > Bison > Cattle > Camelids >>> Badger > Possum • Positive correlation between antibody responses and pathology development • Implications for TB serodiagnosis and new vaccine evaluation

  2. Differential recognition of immunodominant antigens by antibodies during TB in various host species - 1st most frequently recognized - 2nd most frequently recognized - 3rd most frequently recognized

  3. Cattle • Stronger antibody responses are associated with more advanced TB and greater pathology • Cattle • Deer • Badgers • Nonhuman primates • Wild boar • Humans Wild boar NHP -- ESAT-6 -- CFP10 -- Arc1 -- 38 kDa -- Ag85B -- MPB64 -- MPB70 -- MPB83 -- CFP10/ESAT-6 -- Arc1/MPB83 -- MBCF Antibody responses to TB negatively correlate with vaccine efficacy 1 2 3 1 2 3 Hyb-1 + M. tb.M. tb.

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