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Blood supply. Vascular Supply. About 18% of the total blood volume in the body circulates in the brain, which accounts for about 2% of the body weight.
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Vascular Supply • About 18% of the total blood volume in the body circulates in the brain, which accounts for about 2% of the body weight. • The blood transports oxygen, nutrients, and other substances necessary for proper functioning of the brain tissues and carries away metabolites. • Loss of consciousness occurs in less than 15 seconds after blood flow to the brain has stopped, and irreparable damage to the brain tissue occurs within 5 minutes. • Cerebrovascular disease, or stroke, occurs as a result of vascular compromise or hemorrhage and is one of the most frequent sources of neurologic disability. • Nearly half of the admissions to many busy neurologic services are because of strokes. • Cerebrovascular disease is the third most common cause of death in industrialized societies.
BLOOD SUPPLY TO THEBRAIN • High demand for oxygen and nutrients • Arterial blood through: internal carotid andvertebral arteries • Venous blood from brain in the internal jugular veins • Cerebrovascular accidents (CVA): stroke,shutting off blood supply to brain
Arterial supply • The circle of Willis (after the English neuroanatomist Sir Thomas Willis) is a confluence of vessels that gives rise to all of the major cerebral arteries. • Supplied by the paired internal carotid arteries and the basilar artery. • Contains a paired posterior communicating artery and an unpaired anterior communicating artery. • The circle of Willis shows many variations among individuals. • Occlusion of major cerebral arteries produces a characteristic clinical picture.
Why do individual differences in vascular supply matter? • What might they achieve? • What problems might they give? • How might they assist after damage?
VENOUS DRAINAGE • The venous drainage of the brain and coverings includes: • the veins of the brain itself, • the dural venous sinuses, • the dura's meningeal veins, • and the diploic veins between the tables of the skull.
CRANIAL MENINGES • Dura mater: outer and inner layers • Arachnoid mater: epithelial layer and arachnoid trabeculae • Pia mater: sticks to brain surface • Pia and arachnoid = leptomeninges • Dural folds hold the brain in position - Falx cerebri Tentorium cerebelli • Dural sinuses (veins located within the folds)
VENTRICLES OF THE BRAIN • Lined with ependymal cells • Lateral ventricle (each hemisphere) • Third ventricle (diencephalon) • Cerebral aqueduct (midbrain) • Fourth ventricle: (btw pons andcerebellum,continuous with central canal ofspinal cord) • CSF flows within ventricles, central canal and into subarachnoidspace
CEREBROSPINAL FLUID Surrounds and bathes the CNS Functions: 1. Supporting of brain and spinal cord 2. Transport of nutrients, chemical messengers, and waste products
THE FORMATION OF CSF • Choroid plexus: contains specialised ependymalcells and capillaries (500ml/day), total volume:150ml • Choroid plexuses secrete CSF into ventricles • Circulation:from choroid plexus to ventricles and central canalof spinalcord to subarachnoid space to sinuses
Circulation (cont.): • CSF reaches subarachnoid space through two lateral apertures and a single medial aperture in the 4th ventricle • Arachnoid granulations: penetrate dura mater meningeal layer of venous sinuses, CSF absorbed into the venous circulation • Hydrocephalus: “water in the brain”