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Developing CTSA Consortium - NIA collaborations

Developing CTSA Consortium - NIA collaborations. Objectives In collaboration with NIA, stimulate aging research that leverages the power of the CTSA Consortium Establish a draft paradigm for similar collaborations between the CTSA Consortium and other NIH institutes Approach

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Developing CTSA Consortium - NIA collaborations

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  1. Developing CTSA Consortium - NIA collaborations Objectives • In collaboration with NIA, stimulate aging research that leverages the power of the CTSA Consortium • Establish a draft paradigm for similar collaborations between the CTSA Consortium and other NIH institutes Approach Extensive discussions with NIA over 6-12 months explored how the Consortium can provide unique benefit,  and what scientific areas would be attractive for collaborative projects.

  2. Developing CTSA Consortium - NIA collaborations How can the CTSA Consortium provide unique value? • Consortium institutions can leverage resources (e.g. coordinated infrastructure and scientific experts) that can be exceptionally useful in addressing important scientific challenges in aging research • A joint effort between NIA and the Consortium can identify important research opportunities and develop outstanding scientific proposals that take advantage of the unique opportunities afforded by the Consortium

  3. Developing CTSA Consortium - NIA collaborations Select scientific areas of interest Two candidate scientific priorities presented by NIA. The comparative effectiveness of multimodality interventions for a complex geriatric syndrome such as mobility limitation was chosen as an initial project, with the recognition that there may be other compelling opportunities

  4. Developing CTSA Consortium - NIA collaborations Project development Phase 1. Assemble a group of experts to work with NIA to: • identify study design options  for the initial scientific area, considering innovative approaches and unique CTSA Consortium advantages • identify other compelling aging research opportunities for additional collaborations Phase 2.  • Guided by Phase 1, recruit a collaborative group to develop a funding proposal, with the understanding that NIA would approve its submission. Scientific peer review would occur before any funding. • Plan discussed with Barbara Alving who contributed to Phase 1 costs”

  5. Developing CTSA Consortium - NIA collaborations Next step. Invitation to CTSA Principle Investigators requesting nominations of experts to be part of Phase 1. ~10-15 to be selected. Expert characteristics: • Well versed in the value that the CTSA Consortium could bring to a project • Broad knowledge of aging research • Scientific expertise particularly relevant for research in complex geriatric syndromes such as mobility limitation, including assessment of physical function and analyses of multiple risk factors. • Comparative effectiveness research • Clinical trials, including innovative investigative approaches such as adaptive study designs Nominations to be submitted by May 30th To: orwoll@ohsu.edu

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