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Lecture VII. CNS Patterning

Lecture VII. CNS Patterning. Bio 3411 Wednesday September 16, 2009. T. Woolsey 3802 North Building 362-3601 woolseyt@medicine.wustl.edu. Reading. THE BRAIN ATLAS: p 10. Selected References:.

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Lecture VII. CNS Patterning

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  1. Lecture VII. CNS Patterning Bio 3411 Wednesday September 16, 2009

  2. T. Woolsey • 3802 North Building • 362-3601 • woolseyt@medicine.wustl.edu Lecture VII. CNS Patterning

  3. Reading THE BRAIN ATLAS: p 10 Lecture VII. CNS Patterning

  4. Selected References: † Benito-Gutierrez, E., & Arendt, D. (2009). CNS evolution: new insight from the mud. Curr Biol, 19(15), R640-642. Hamilton, W. J., Boyd, J. D., & Mossman, H. W. (1972). Hamilton, Boyd and Mossman's human embryology; prenatal development of form and function (4th ed.). Cambridge,: Heffer. †Hartenstein, V. (1993). Atlas of Drosophila Development. Kandel, E. R., Schwartz, J. H., & Jessell, T. M. (2000). Principles of neural science (4th ed.). New York: McGraw-Hill, Health Professions Division. Chapter 52, pp 1019-1040. †Puelles, L. (2009). Forebrain Development: Prosomere Model. in: New Encyclopedia of Neuroscience. Amsterdam: Elsevier. Ranson, S. W., & Clark, S. L. (1959). The anatomy of the nervous system; its development and function (10th ed.). Philadelphia,: Saunders. –––––––––––––– † Posted on web site. Lecture VII. CNS Patterning

  5. What the last Lecture was about • General mechanisms for assembling neurons and groups of neurons • Diffusion vs Contact • Attraction vs Repulsion  • Examples of impacts of contact  • Examples of impacts of diffusion • Specification by growth factors • The chemoaffinity hypothesis Lecture VII. CNS Patterning

  6. What this Lecture is about • The Initiation of the Central Nervous System • CNS Growth and Pattern Development • Bug Brains • Several Mechanisms for Directing the Show (scripts conserved) • How did vertebrate and invertebrate patterns arise? Lecture VII. CNS Patterning

  7. Recap of Early Embryogenesis Lecture VII. CNS Patterning

  8. Ranson & Clark (1959) Lecture VII. CNS Patterning

  9. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  10. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  11. From Tube to Brain Lecture VII. CNS Patterning

  12. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  13. THE BRAIN ATLAS 3rded, p.10 Lecture VII. CNS Patterning

  14. Hamilton, Boyd, & Mossman (1972) Lecture VII. CNS Patterning

  15. Hamilton, Boyd, & Mossman (1972) Lecture VII. CNS Patterning

  16. Hamilton, Boyd, & Mossman (1972) Lecture VII. CNS Patterning

  17. Hamilton, Boyd, & Mossman (1972) Lecture VII. CNS Patterning

  18. Hamilton, Boyd, & Mossman (1972) Lecture VII. CNS Patterning

  19. Hamilton, Boyd, & Mossman (1972) Lecture VII. CNS Patterning

  20. From Fly Egg to Fly Brain Lecture VII. CNS Patterning

  21. Hartenstein (1993) Lecture VII. CNS Patterning

  22. Hartenstein (1993) Lecture VII. CNS Patterning

  23. Hartenstein (1993) Lecture VII. CNS Patterning

  24. Hartenstein (1993) Lecture VII. CNS Patterning

  25. Segmentation and Signals Lecture VII. CNS Patterning

  26. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  27. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  28. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  29. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  30. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  31. Kandel, Schwartz, & Jessell (2000) Lecture VII. CNS Patterning

  32. Ancient Choice? Lecture VII. CNS Patterning

  33. Benito-Gutierrez & Arendt, (2009) Lecture VII. CNS Patterning

  34. Benito-Gutierrez & Arendt, (2009) Lecture VII. CNS Patterning

  35. What this Lecture was about • The Initiation of the Central Nervous System • CNS Growth and Pattern Development • Bug Brains • Several Mechanisms for Directing the Show (scripts conserved) • How did vertebrate and invertebrate patterns arise? Lecture VII. CNS Patterning

  36. Reflections • Early events initiating the nervous system • Beginning the sculpture – proliferation and death mechanisms • Signals for functional and connectional specificity – contact, distance, for or against • The pattern and organization emerges • Generalizations made but questions unanswered Lecture VII. CNS Patterning

  37. Sequential Restrictions (Refinements) are the Bases for Development (and plasticity) pluripotent, stem cell genetic environmental differentiated Lecture VII. CNS Patterning

  38. Lecture VII. CNS Patterning

  39. http://embryo.soad.umich.edu/ Lecture VII. CNS Patterning

  40. Finis Lecture VII. CNS Patterning

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