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Draw a reaction map of glucose completely metabolized to CO 2 + H 2 O in the presence of oxygen 25 Points Reference: http://employee.heartland.edu/hfei/ Under: Biol 161-02 / Class Materials / Unit 2 / Lecture Slides / Chapter 8 Requiresments : Chemical formula;
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Draw a reaction map of glucose completely metabolized to CO2 + H2O in the presence • of oxygen 25 Points • Reference: http://employee.heartland.edu/hfei/ • Under: • Biol 161-02 / Class Materials / Unit 2 / Lecture Slides / Chapter 8 • Requiresments: • Chemical formula; • Enzymes, co-enzymes, and co-products; 15 points • Calculate ATP formation through aerobic metabolism. Adding up of ATPs from four courses: • direct formation by a reaction • from GTP • from NADH • from FAD2 5 points • Trace C1 of glucose through the pathway as far as you can. 5 points Bonus (2 points): If C1 of glucose is labeled, how many rounds of Krebs Cycle do you expect it to take for it to be completely released as CO2?
Hexokinase p-hexoseisomerase p-fructokinase Glucose-6-Phosphate G6P Fructose-6-Phosphate F6P Fructose-1,6-bisphosphate Glucose Aldolase Glyceraldehyde 3phosphate dehydrogenase Phosphoglyceratekinase Mutase Isomerase Glyceraldehyde 3phosphate Dihydroxy acetone 1,3 bisphosphoglycerate 2-Phosphoglycerate 3-Phosphoglycerate Enolase (SPONTANEOUS) PyruvateKinase Phosphoenopyruvate Enopyruvate Pyruvate CYTOSOL O C -OH MITOCHONDRION C=O CH3 Pyruvate
MITOCHONDRION CITRIC ACID CYCLE CETATE Isocitrate dehydrogenase Aconitase CETATE Isocitrate CETATE CoA Citrate a-Ketoglutarate dehydrogenase a-Ketoglutarate Citrate synthase Pyruvatedehudrogenase complex CETATE Acetyl CoA CETATE Pyruvate Succinyl-CoA SuccinylCoA synthase Oxaloacetate O CETATE C -OH Malatedehydrogenase C=O CETATE CH3 Succinate CETATE SuccinylCoA dehydrogenase Fumarase Malate Fumarate