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Structural hierarchy in proteins

Structural hierarchy in proteins. The reaction of dansyl chloride in end group analysis. The hypothetical rate of the carboxypeptidase-catalyzed release of amino acids: all bonds cleaved at the same rate.

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Structural hierarchy in proteins

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  1. Structural hierarchy in proteins

  2. The reaction of dansyl chloride in end group analysis

  3. The hypothetical rate of the carboxypeptidase-catalyzed release of amino acids: all bonds cleaved at the same rate

  4. The hypothetical rate of the carboxypeptidase-catalyzed release of amino acids: Ser slow, Tyr fast, and Leu intermediate

  5. Specificities of various exopeptidases

  6. Specificities of various endopeptidases

  7. Edman degradation

  8. The amino acid sequence of a polypeptide chain

  9. Primary structure of bovine insulin

  10. Flow diagram for polypeptide synthesis by the solid phase method

  11. Amino acids with benzyl-protected side chains and Boc-protected a-amino groups

  12. Connecting two peptides: native chemical ligation

  13. END

  14. Amino Acid Sequences of Cytochromes c from 38 species

  15. Amino Acid Sequences of Cytochromes c from 38 Species

  16. Amino Acid Difference Matrix for 26 Species of Cytochrome ca

  17. The PAM-250 Log Odds Substitution Matrix

  18. Flow diagram of the chain-terminator (dideoxy) method of DNA sequencing

  19. Autoradiograph of a sequencing gel

  20. A portion of the output of a four reaction/one gel sequencing system

  21. Genome sequencing strategies

  22. Scanning electron microscope of human erythrocytes. (a) Normal human erythrocytes revealing their biconcave disklike shape

  23. Scanning electron microscope of human erythrocytes. (b) Sickled erythrocytes from an individual with sickle-cell anemia

  24. A map indicating the regions of the world where malaria caused by P. falciparum was prevalent before 1930

  25. Phylogenic tree of cytochrome c

  26. Rates of evolution of four unrelated proteins

  27. A phylogenetic tree for cytochrome c

  28. Phylogenetic tree of the globin family

  29. Rate of sequence change in evolving proteins. (a) Protein evolving at random and that initially consists of 5% each of the 20 “standard” amino acid residues

  30. Rate of sequence change in evolving proteins. (b) A protein of average amino acid composition evolving as is observed in nature

  31. Sequence alignment with dot matrices

  32. The optical alignments of human myoglobin (Mb, 153 residues) and the human hemoglobin a chain (Hba, 141 residues)

  33. A guide to the significance of normalized alignment scores (NAS) in the comparison of peptide sequences

  34. Use of the Needleman-Wunsch alignment algorithm [alignment of 10-residue peptide (horizontal) with 11-residue peptide (vertical)]. (a) Comparison matrix

  35. Use of the Needleman-Wunsch alignment algorithm [alignment of 10-residue peptide (horizontal) with 11-residue peptide (vertical)]. (b) Transforming the matrix

  36. Use of the Needleman-Wunsch alignment algorithm [alignment of 10-residue peptide (horizontal) with 11-residue peptide (vertical)]. (c) Transformed matrix

  37. Phylogenetic trees

  38. An unrooted phylogenetic tree of the five HIPIP sequences that are aligned in Fig. 7-30c

  39. Manipulations employed in the neighbor-joining method for the construction of a phylogenetic tree

  40. A DNA chip

  41. The photolithographic synthesis of a DNA chip

  42. Variation in the expression of genes that encode proteins known as cyclins (Section 34-4C) in human tissues

  43. Some Sequenced Genomes

  44. Some Sequenced Genomes

  45. Amino acid analysis via HPLC

  46. The generation of the gas phase ions required for the mass spectrometric analysis of proteins: electrospray ionization(ESI)

  47. The generation of the gas phase ions required for the mass spectrometric analysis of proteins: matrix-assisted laser desorption/ionization (MALDI)

  48. The generation of the gas phase ions required for the mass spectrometric analysis of proteins: fast atom bombardment (FAB)

  49. The ESI-MS spectrum of the 17 kD horse heart protein apomyoglobin

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