DRUGS USED FOR TREATMENT OF EPILEPSY

1. DRUGS USED FOR TREATMENT OF EPILEPSY Prof. Mohammad Saad AL-Humayyd

2. Antiepileptic drugs

3. Definition • Epilepsy is a chronic medical condition characterized by 2 or more unprovoked seizures. • It is not a disease, it is a syndrome (what is the difference ? ) • What is the difference between seizure & epileptic syndrome?

5. Phenylalanine hydroxylase Etiology • Congenital defects, head injuries, trauma, hypoxia • Infection ( bacteria or virus ) e.g. meningitis, brain abscess, viral encephalitis. • Concussion, depressed skull, fractures. • Brain tumors (including tuberculoma), vascular occlusion, stroke. • Drug withdrawal, e.g. CNS depressants,alcohol or drug abuse or drug overdose,e.g. penicillin. • A poison, like lead • Fever in children (febrile convulsion). • Hypoglycemia • PKU(phenylalanine tyrosine ) • Photo epilepsy

6. Triggers • Fatigue • Stress • Sleep deprivation • Poor nutrition • Alcohol

7. Classification of Epilepsy

9. [c] Secondarily generalized seizure Begins as partial (simple or complex) and progress into grand mal seizure

11. General rules for treatment of epilepsy Epilepsy is usually controlled but not cured with medication. Upto 80% of pts can expect partial or complete control of seizures with appropriate treatment. Antiepileptic drugs are indicated when there is two or more seizures occurred in short interval ( 6 m -1y) An initial therapeutic aim is to use only one drug (monotherapy).

12. Drugs are usually administered orally Monitoring plasma drug level is useful Triggering factors can affect seizure control by drugs. Sudden withdrawal of drugs should be avoided

13. Withdrawal considered Seizure –free period of 2-5 yrs or longer Normal IQ Normal EEG prior to withdrawal NO juvenile myoclonic epilepsy Relapse rate when antiepileptics are withdrawnis 20-40%.

14. Pathophysiology of Epilepsy How Drugs Act? • Blockade of voltage –gated channels (Na+ or Ca+) • Enhancement of GABA Or interference with • Glutamate transmission (citatory) (inhibitory)

15. Classification of antiepileptic drugs First-generation • Phenytoin** • Carbamazepine** • Valproate** • Phenobarbital and Primidone • Benzodiazepines (e.g.Clonazepam, lorazepam and diazepam) Second- generation • Lamotrigine** • Levetiracetam** • Topiramate ** • Gabapentin • Vigabatrin • Felbamate • Zonisamide

16. Phenytoin Pharmacokinetics : • Well absorbed orally, it is also available i.v • Enzyme inducer • Metabolized by the liver to inactive metabolites • Excreted in urine

17. Phenytoin Mechanism of action • Blockade of Na+ & Ca + + influx into neuronal axon. • Inhibit the release of excitatory transmitters • Potentiate the action of GABA Therapeutic uses: • Partial and generalized tonic-clonic seizures Not in absence seizure. • In status epilepticus, IV .

18. Side effects • Nausea or vomiting • Neurological like headache, vertigo, ataxia, diplopia , nystagmus • Sedation • Gum hyperplasia • Hirsutism • Acne • Megaloblastic anemia • Osteomalcia • Teratogenic effect

19. Carbamazepine • Pharmacokinetics : • Available only orally • Well absorbed • Strong enzyme inducer including its own metabolism • Metabolized by the liver to active & inactive metabolites • Excreted in urine

20. Carbamazepine Mechanism of action • Blockade of Na+ & Ca + + influx into neuronal axon. • Inhibit the release of excitatory transmitters • Potentiate the action of GABA Therapeutic uses: • Drug of choice in partial seizures. • Tonic-clonic seizures (1ry & 2ry generalized) but Not in absence seizures.

21. Side effects • GIT upset. • Hypersensitivity reactions • Drowziness , ataxia, headache & diplopia • Blood dyscrasis • Hyponatremia& water intoxication • Teratogenicity

22. Sodium ValproateBroad spectrum antiepileptic • Pharmacokinetics : • Available as capsules, Syrup , I.V • Metabolized by the liver ( inactive ) • Enzyme inhibitor • Excreted in urine

23. Sodium valproate Mechanism of action • Blockade of Na+ channels. • Inhibits GABA -transaminase • Suppress glutamate action. Therapeutic Uses [I] Epilepsy: It is effective for all forms of epilepsy e.g. • Generalized tonic-clonic seizures (1ry or 2ry ). • Absence seizures • Complex partial seizures • Myoclonic • Atonic • photosensitive epilepsy

24. Side effects: • Weight gain (appetite ). • Transienthairloss, with re-growth of curly hair • Thrombocytopenia • Hepatotoxicity • Teratogenicity

25. Lamotrigine Mechanism of action • Blockade of Na+ channels • Inhibits excitatory amino acid release ( glutamate & aspartate ) Therapeutic Use • As add-on therapy or as monotherapy in partial seizures • Lennox-Gastaut syndrome

26. Pharmacokinetics Available as oral tablets Well absorbed from GIT Metabolized primarily by glucuronidation Does not induce or inhibit C. P-450 isozymes

27. Side effects • Influenza-like symptoms. • Skin rashes (may progress to Steven –Johnson syndrome ) • Somnolence • Blurred vision • Diplopia • Ataxia

28. Levetiracetam • Pharmacokinetics : • Taken orally ( tablets or solutions) • Not metabolized & excreted unchanged in urine • Does not affect liver enzymes • Drug interactions are minimal

29. Levetiracetam Mechanism of action • Unknown Therapeutic Uses Adjunctive therapy in : • Partial seizures • Generalized tonic-clonic seizures • Myoclonic seizures (used alone)

30. Side effects • Ataxia • Dizziness • Somnolence • Pin & needles sensation in extremities • Blurred vision

31. Topiramate Pharmacological Effects: • Well absorbed orally ( 80 % ) • Food has no effect on absorption • Has no effect on microsomal enzymes • 9-17 % protein bound ( minimal ) • Mostly excreted unchanged in urine • Plasma t1l2 18-24 hrs Mechanism of Action: • Blocks sodium channels (membrane stabilization) and also potentiates the inhibitory effect of GABA.

32. Topiramate ( Cont. ) Clinical Uses: • Can be used alone for partial, generalized tonic-clonic, and absence seizures. • Lennox- Gastaut syndrome ( or lamotrigine, or valproate ). Side effects: • Psychological or cognitive dysfunction • Weight loss ( can be desirable side effect) • Sedation • Dizziness • Fatigue • Urolithiasis • Paresthesias (abnormal sensation ) • Teratogenecity (in animal but not in human)

34. Drugs used for treatment of Status Epilepticus • Most seizures stop within 5 minutes. When seizures follow one another without recovery of consciousness, it is called “status epilepticus”. It has a high mortality rate . Death is from cardiorespiratory failure.

35. Intravenous injection of : • Lorazepam is the drug of choice • Diazepam • Phenytoin • Fosphenytoin • Phenobarbital .

36. Vagal nerve stimulation • It is an alternative for patients who have been refractory to multiple drugs . • Who are sensitive to the many adverse effects of anti epileptic drugs • It is an expensive procedure

38. Pregnancy & antiepileptics Seizure is very harmful for pregnant woman. NO antiepileptic drug is safe in pregnancy. Monotherapy usually better than drug combination. Valproate & phenytoin are contraindicated during pregnancy. Patient has to continue therapy. If follow up of pregnancy reveals teratogenic effect, terminate pregnancy.

39. Summary • - Epilepsy is classified into partial or generalized according to the site of lesion. • The exact mechanism of action of antiepileptics is not known. • Phenytoin is mainly used for treatment of generalized tonic-clonic seizures . Carbamazepine is mainly used for treatment of partial seizures

40. Summary ( con.) • Sodium valproate is a broad spectrum antiepileptic drug. • Lamotrigine & levetiracetam are used as monotherapy or adjunctive therapy in refractory cases. • Lorazepam , diazepam , phenytoin are used intravenously for treatment of status epilepticus.

41. Objectives At the end of the lectures, students should 1- Describe types of epilepsy 2- List the antiepileptic drugs 3- Describe briefly the mechanism of action of antiepileptic drugs. 4- Enumerate the clinical uses of each drug 5- Describe the adverse effects of each antiepileptic drug 6- Describe treatment of status epilepticus