YOU CANNOT CREATE A CHIRAL RESULT BY REACTION OF TWO ACHIRAL SUBSTANCES

1. YOU CANNOT CREATE A CHIRAL RESULT BY REACTION OF TWO ACHIRAL SUBSTANCES Examples using the stereospecific cis-hydrogenation reaction ….. that is – a syn addition

2. INTERACTION OF ACHIRAL OBJECTS GIVES AN ACHIRAL RESULT meso achiral catalyst achiral top achiral planar alkene (cis) 50/50 but: IDENTICAL both meso bottom achiral catalyst achiral meso NOT A CHIRAL RESULT

3. INTERACTION OF ACHIRAL OBJECTS GIVES AN ACHIRAL RESULT achiral catalyst top achiral planar alkene (trans) Racemic Mixture 50/50 Enantiomers bottom achiral catalyst A RACEMIC MIXTURE IS NOT A CHIRAL RESULT (you do not get a specific enantiomer)

4. INTERVENTION OF A CHIRAL INTERMEDIARY GIVES A CHIRAL RESULT not formed specific binding Enzyme (chiral) blocks top side X Me Et achiral alkene one enantiomer achiral catalyst or an achiral reagent CHIRAL RESULT

5. INTERVENTION OF A CHIRAL INTERMEDIARY GIVES A CHIRAL RESULT not formed X alkene only fits one way into active site Me one enantiomer Me chiral catalyst enzyme is the reagent CHIRAL RESULT