1 / 9

Gastric Polyps: Protons, Spirochetes and hyperplasia

Gastric Polyps: Protons, Spirochetes and hyperplasia. Damian Paton-Gay Jan 2007. The Plan…. A quick look at the epidemiology and major types of polyps Do PPI’s cause polyps? Does H. pylori infection cause polyps? What do gastric polyps have to do with colonic adenomas and carcinomas?.

china
Download Presentation

Gastric Polyps: Protons, Spirochetes and hyperplasia

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Gastric Polyps:Protons, Spirochetes and hyperplasia Damian Paton-Gay Jan 2007

  2. The Plan…. • A quick look at the epidemiology and major types of polyps • Do PPI’s cause polyps? • Does H. pylori infection cause polyps? • What do gastric polyps have to do with colonic adenomas and carcinomas?

  3. Epidemiology • A few large epidemiological studies • Incidence 1-3% of gastroscopies

  4. Frequency and Types of Polyps

  5. Fundic Gland Polyps • Often multiple 2-3 mm sessile lesions in body and fundus • “Focal increase in glandular elements” • Sporadic in general population • 53% incidence in FAP • Almost invariably benign • 3 case reports of gastric ca in a fundic gland polyp in a pt with FAP

  6. Hyperplastic Polyps • Usually solitary <1.5 cm sessile lesions in body • Described as “shinier” and softer than other polyps • May have an umbilicated center • Higher risk of harbouring dysplasia than fundic gland polyps • These have been associated with H. pylori (more later)

  7. Hyperplastic Polyps • Risk of developing adenocarcinoma in a hyperplastic polyp is considered ~2% • Based on a study of 477 hyperplastic polyps in 1990 • Daibo M et al. Malignant Transformation of Gastric Hyperplastic Polyps. Am J Gastroenterol. 1990 Mar;85(3):327-8

  8. Adenomas • Usually solitary and sessile polyps • Most often antral • Often quite large (10+ cm in diameter) • Very similar to colonic polyps…. • Can be tubular, tubulovillous or villous • Premalignant lesions • Incidence of carinoma is between 3 and 11%

  9. Adenomas continued • As with colonic polyps • Risk of Ca ^’s with polyp size and histologic type • Also - the presence of a gastric adenoma increases the risk of carcinoma elsewhere in the stomach

More Related