1 / 4

Intestinal structure

Intestinal structure. Structure Crimpy structure to facilitate the contacts between nutrients and absorptive cells Extends surface area to 300 m 2 Functions Lined by a single layer of enterocytes Efficient structure for absorption of nutrients

chinue
Download Presentation

Intestinal structure

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Intestinal structure • Structure • Crimpy structure to facilitate the contacts between nutrients and absorptive cells • Extends surface area to 300 m2 • Functions • Lined by a single layer of enterocytes • Efficient structure for absorption of nutrients • Not an effective structure for barrier function • To effectively block pathogens • Barrier system • Gut-associated immune system (Illustration: courtesy of the University of Waikato)

  2. Intestinal structure Capillaries leading to portal veins underneath the single layer of enterocytes Any damage in enterocytes will open up primary barrier function and pigs will be exposed to infections (photo: courtesy of Southern Illinois University, School of Medicine)

  3. Intestinal immune system – antigen uptake as a surveillance system • Antigen sampling through M cell • Preparing possible open up of intestinal barrier and pathogen invasion • Require energy and protein • Perform less efficiently in a dirty environment Nature Reviews Immunology, Mowat et al., 2003

  4. Physical barriers in the monolayer of enterocytes Paracellular permeability is directly related to pathogen translocation into the body system and TJ plays a key role Loose tight junction causes “leaky gut” Groschwitz and Hogan, 2009

More Related