60 likes | 199 Views
Osteoclastic Metabolism of 25(OH)-Vitamin D3: A Potential Mechanism for Optimization of Bone Resorption. Osteoscoop - Issue N°166 - January 2011. 25D. CYP27B1. 1,25D. 25D. CYP27B1. 1,25D. 1,25D. VDR. Osteoclast precursor. 25D. M-Csf. Rank ligand. CYP27B1. 1,25D. 1,25D. VDR.
E N D
Osteoclastic Metabolismof 25(OH)-Vitamin D3: A Potential Mechanism forOptimization of Bone Resorption Osteoscoop - Issue N°166 - January 2011
25D CYP27B1 1,25D
25D CYP27B1 1,25D 1,25D VDR
Osteoclast precursor 25D M-Csf Rank ligand CYP27B1 1,25D 1,25D VDR
Osteoclast precursor Mature osteoclast 25D M-Csf Rank ligand CYP27B1 1,25D + 1,25D VDR
Osteoclast precursor Mature osteoclast 25D M-Csf 25D Rank ligand CYP27B1 CYP27B1 1,25D 1,25D + 1,25D VDR Inhibition of bone resorption