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The Life Cycle of an NIH Grant Application

The Life Cycle of an NIH Grant Application. Alicia Dombroski, Ph.D. Deputy Director Division of Extramural Activities NIDCR. A Grant Application Starts with a Great Idea. Who? Scientists at Colleges, Universities, Research Institutes, Small Businesses, Others What?

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The Life Cycle of an NIH Grant Application

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  1. The Life Cycle of an NIH Grant Application Alicia Dombroski, Ph.D. Deputy Director Division of Extramural Activities NIDCR

  2. A Grant Application Starts with a Great Idea • Who? Scientists at Colleges, Universities, Research Institutes, Small Businesses, Others • What? Research relevant to human health Basic, applied, behavioral, translational, clinical

  3. Types of NIH Applications • Research Projects • Unsolicited (R01most common) • Responding to specific Funding Opportunity Announcement • Individual or consortium • Small Business Grants • Small business innovation research (SBIR) • Small business technology transfer (STTR) • Training and Career Development • Predoctoral, postdoctoral, dual degree, mentored career development, etc. • Individual or Institutional

  4. Preparation of an Application • Interaction with NIDCR Program Staff • Does the proposed research support the mission of the institute? • Is the topic a high priority for the institute? • Forms and Instructions online • Face page • Budget and budget justification • Personnel • Research plan

  5. Electronic Submission Applicant organization must register in Grants.Gov and NIH eRA Application must be signed and submitted by a business official at the applicant organization

  6. Receipt and Referral Center for Scientific Review (CSR) at NIH receives all NIH Applications (~80,000 per year) Determines locus of peer review (CSR or Institute) Assigns Integrated Review Group (study section) Assigns Institute based on scientific area

  7. NIH Peer Review • Panel of experts in appropriate scientific areas • Applications assigned for critique and discussion • Evaluation of scientific and technical merit • Meets in person, teleconference, or internet • Specific review criteria: Significance, Approach, Innovation, Investigator, Environment • Applications are scored (1.0-5.0, with 1.0 best) • Investigators receive score and summary statement

  8. Funding Decisions • Factors: • Scientific Merit – score, reviewer comments • Contribution to the mission of NIDCR • Program priorities and portfolio balance • Availability of funds • Variables: • Award period • Total amount of award • Specific budget items

  9. Secondary Review • National Advisory Dental and Craniofacial Research Council (NADCRC) • Advises, consults, makes recommendations • Membership: • 2 non-voting ex officio (DOD, VA) • 13 scientists/clinicians/public • 4 year term • Applications can only be funded after review by NADCRC and concurrence with initial review outcome

  10. Other Post-Review Activities • Awards administered by NIDCR Grants Management Officer • Annual progress reports and financial status reports • End of award/competing renewal • If Not Funded: • Discussions between Applicant and NIDCR Scientific Program Staff • Review issues • Programmatic issues • Resubmission of revised application (up to 2 revisions) • Three cycles per year for unsolicited applications • Receipt date, review date, council date each cycle

  11. NIDCR Scientific Program Staff Score Principal Investigator Grant Application Peer Review NIDCR Grants Management

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