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ABSTRACT

ABSTRACT. Combination therapy is the methode of overcoming the global challenge of drug-resistant malaria. Three models of combination therapy of ethanolic extract 80% sambiloto ( Andrographis paniculata Nees.) and curcumin were evaluated in vivo for

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ABSTRACT

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  1. ABSTRACT Combination therapy is the methode of overcoming the global challenge of drug-resistant malaria. Three models of combination therapy of ethanolic extract 80% sambiloto (Andrographis paniculata Nees.) and curcumin were evaluated in vivo for potentiation against mice infected Plasmodium berghei by oral route. A five-day dosage (D0-D4) of combination ethanolic extract 80% sambiloto 100 mg/kg body weight and curcumin 100 mg/kg (I model) produce inhibition of parasite’s growth for 25,99% and survival monitored for 11-13 days. A five-day dosage (D0-D4) of combination ethanolic extract 80% sambiloto 100 mg/kg body weight and curcumin 10 mg/kg (II model) produce inhibition of parasite’s growth for 23,83% and survival monitored for 9-12 days. The third combination is ethanolic extract 80% sambiloto 100 mg/kg body weight and curcumin 1 mg/kg (III model) produce inhibition of parasite’s growth for 9,03% and survival monitored for 9-11 days. Key words : Andrographis paniculata extract, curcumin, combination therapy, antimalarial

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