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DNA, RNA, and DNA Replication. DNA vs RNA. Deoxyribonucleic Acid Double Helix Shaped Forms: Nuclear Mitochondrial Chromosomal Never leaves Nucleus Contains C,G, A, T. Ribonucleic Acid Single Helix Shaped Forms: Messenger Transfer Ribosomal
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DNA vs RNA • Deoxyribonucleic Acid • Double Helix Shaped • Forms: Nuclear Mitochondrial Chromosomal • Never leaves Nucleus • Contains C,G, A, T • Ribonucleic Acid • Single Helix Shaped • Forms: Messenger Transfer Ribosomal • Leaves Nucleus • Contains C, G, A, U
DNA Base Pairing • Adenine bonds with Thymine • Cytosine bonds with Guanine • A-T or T-A • C-G or G-C
RNA Base Pairing • Adenine bonds with Uracil • Cytosine bonds with Guanine • A-U or U-A • C-G or G-C
DNA Structure • Phosphate Group (PO4) • Deoxyribose Sugar • Nitrogen Base Pair • Deoxyribose Sugar • Phosphate Group (PO4)
DNA Structure Mobile • Color each part. • Cut out the individual pieces. • Glue or paste together. • Attach string for individual mobiles. • Tape all of the classses together and make a huge strand to hang from ceiling. • Attach to cardboard and make a puzzle.
DNA Replication • Replication = DNA copies itself exactly • (Occurs within the nucleus) • Any mistake in copying = mutation • DNA mutation = chromosomal mutation
Basic Facts of DNA Replication 1. Complementary base pairing makes replication possible C - G A - T
Basic Facts of DNA Replication 2. One side of DNA molecule is a template for making the other side (strand)
Process of DNA Replication • Uncoil & unzip DNA molecule • Enzyme (-ase) breaks weakHydrogen Bond between bases
Process of DNA Replication 2. Enzyme brings in complementary N-bases DNA Replicase
Process of DNA Replication 3. Insert N-bases DNA Replication Tutorial (Go here for on-your-own learning/review) trc.ucdavis.edu/.../week5/06dnareplication.html
Replication Movie C - G A- T
Semi-conservative replication • Each new DNA molecule contains one old strand & one new strand
QUESTIONS TO KNOW • What is the shape of DNA?
QUESTIONS TO KNOW • A Double Helix
QUESTIONS TO KNOW • Where is DNA found within the cell?
QUESTIONS TO KNOW • In the nucleus only.
QUESTIONS TO KNOW • What is the result of a mistake in the copying portion of DNA replication called?
QUESTIONS TO KNOW • A mutation
QUESTIONS TO KNOW • Cytosine bonds with?
QUESTIONS TO KNOW • Guanine
QUESTIONS TO KNOW • Adenine bonds with what in DNA? RNA?
QUESTIONS TO KNOW • Thymine • Uracil
QUESTIONS TO KNOW • What is the opposite DNA base pair of: C-T-A-G-G-C-T-T-A-A-C-G-G-T-T-A-C
QUESTIONS TO KNOW • C-T-A-G-G-C-T-T-A-A-C-G-G-T-T-A-C G-A-T-C-C-G-A-A-T-T-G-C-C-A-A-T-G
QUESTIONS TO KNOW • Which base pair is that of RNA? 1. C-T-A-G-G-C-T-T-A-A-C-G-G-T-T-A-C 2. C-A-U-G-G-C-A-A-U-U-G-C-C-U-U-G 3. G-T-U-C-C-G-T-U-T-U-C-G-G-T-A-C
QUESTIONS TO KNOW 1. C-T-A-G-G-C-T-T-A-A-C-G-G-T-T-A-C 2. C-A-U-G-G-C-A-A-U-U-G-C-C-U-U-G 3. G-T-U-C-C-G-T-U-T-U-C-G-G-T-A-C