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Infant Feeding: Human Milk and Formula Joan C Zerzan MS RD CD. “No two hemispheres of any learned professor’s brain are equal to two healthy mammary glands in the production of a satisfactory food for infants” - Oliver Wendell Holmes. Characteristics and Advantages of Human Milk.
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Infant Feeding: Human Milk and Formula Joan C Zerzan MS RD CD
“No two hemispheres of any learned professor’s brain are equal to two healthy mammary glands in the production of a satisfactory food for infants” - Oliver Wendell Holmes
Characteristics and Advantages of Human Milk • Low renal solute load • Immunologic, growth and trophic factors • Decrease illness, infection, allergy • Improved digestion and absorbtion • Nutrient Composition: CHO, Protein, Fatty Acid, etc • Cost • Other
Infant Feeding: Historical Perspective • Breast feeding • Human Milk Substitutes • Science, Medicine and Industry
Human Milk Substitutes • Wet nurses • Other mammalian milk (cow, goat, donkey, camel) • Pablum: bread/flour, mixed with water • “bread, water, flour, sugar and castille soap to aid digestion”
Human Milk Substitutes • 1915 Gerstenberger developed first “complete infant formula” marketed as SMA (synthetic milk adapted) • Base was defatted and diluted cow’s milk with beef tallow added to mimic the fat content of human milk
Human Milk Substitutes • 1920-1950’s: evaporated or fresh cow’s milk, water and added CHO (prepared at home) • 1950’s to present commercially prepared infant formulas have replaced home recipes
Science, Medicine, and Industry • Infant Morbidity and Mortality • Recognition of association with human milk substitutes, and infection • Industrial development • Storage • Safety • Food industry
Science, Medicine, and Industry Growth of child Health and welfare in early 20th century
1900 Pasteurization of milk in US Association between bacteria and diarrhea 1912 U.S Children’s Bureau Public Health and Pediatricians efforts to improve infant/child health and decrease mortality 1920 Intro evaporated milk Cod liver oil prevents rickets Curd tension of milk altered Increased availability of refrigeration Vitamin C isolated Vitamin D prepared in pure form Improved sanitation Historical timeline
1940 Homogenized milk widely marketed 1960 Further advances in technology and packaging Commercially prepared infant formula becoming increasingly popular Historical timeline
Regulation of Infant Formula • FDA • Infant Formula Act • Manufacturers • Voluntary monitoring • AAP, National Academy of Sciences, other professional organizations • Guidelines for composition and intake: (e.g. DRI’s) • Guidelines for preparation and handling of formula/human milk in health care facilities
Regulation of Infant Formulas • Infant Formula Act: The purpose of the infant formula act (1980) is to ensure the safety and nutrition of infant formulas – including minimum and in some cases maximum levels of specified nutrients. The act authorizes the FDA to establish appropriate regulations for 1) new formulas, 2) formulas entering the U.S. market, 3) major changes, revisions, or substitutions of macronutrients 4) formulas manufactured in new plants or processing lines, 5) addition of new constituents 6) use of new equipment or technology 7) packaging changes
Regulation of Infant Formulas • Infant Formula Act: • Manufacturing regulations • Quality control • Non specific testing requirements, case by case basis, growth outcomes • Recall Proceedures • Nutrient content and labeling • Panel convened 1998 and 2002 (recommended revisions including exemptions)
Formula Composition • Breast Milk as “gold standard” • Attempt to duplicate composition of breastmilk • ? Bioactivity, relationship, function of all factors present in breast milk • ? Measure outcome: growth, composition, functional indices
Approaches to Estimating Nutrient Requirements • Direct experimental evidence • ie protein and amino acids • extrapolation from experimental evidence relating to human subjects of other age groups or animal models • ie thiamin--related to energy intake .3-.5 mg/1000 kcal • Breast milk as gold standard • ie average [ ] X usual intake • Metabolic balance studies • ie protein, Ca, Mg, Cu, Zn (may be overestimate) • Clinical Observation • ie formula manufacturing errors B6, Cl • Factorial approach
Feeding the Infant • Choices: • Human Milk • Standard Infant Formula (Cow, Soy) • Hypoallergenic (hydrolysates vs amino acid based • Other specialty formulas • Preterm • Post discharge formulas for preterm infants
Feeding the Infant • Considerations • Infant (needs, tolerance, acceptance, safety) • Indications • Family preferences • Cost • availability
Formula Brands • Ross • Similac/Isomil/Alimentum • Mead Johnson • Enfamil/Prosobee/Enfacare • Nestle • Good Start • Wyeth • Generic in USA; Gold Brands; SMA • SHS • NeoCate, DuoCal
Milk Based Formulas • Standard 0-12 months • Similac with iron • Enfamil with iron • Good Start Essentials/Good Start Supreme • Wyeth Generic • Standard 0-12 mos with DHA/ARA • Similac Advance with iron • Enfamil Lipil with iron • Good Start Supreme DHA/ARA • Wyeth formulas
Milk Based FormulasCharacteristics • Blend of Whey and Casein Proteins (8.2-9.6 % total calories) • Carbohydrate: lactose • Fats: long chain • Meet needs of healthy infant
Soy Formulas • Isomil/Isomil DF /Isomil Advance/Isomil Advance 2 • Prosobee/Prosobee Lipil/Next Step Prosobee • Good Start Essentials Soy/Good Start 2 Essentials Soy • Wyeth All iron fortified
Soy FormulasCharacteristics compared to Milk Based • Higher protein (lower quality) • Higher sodium, calcium, and phosphorus • Carbohydrate: Corn syrup solids, sucrose, and/or maltodextrin; lactose free • Fats: Long chain • Meet needs of healthy infants
Protein Hydrolysate Formulas • Alimentum Advance • Pregestimil/Pregestimil Lipil • Nutramigen Lipil • Protein Casein hyrolysate + free AA’s • Fat (Alimentum and Pregestimil) Medium chain + Long chain triglycerides; (Nutramigen) Long chain triglycerides • Carbohydrate: Lactose free
Elemental Infant Formula • NeoCate (SHS) • Protein: Free Amino Acids • Fat: Long chain • Carbohydrate: Lactose Free • Indications for use: Food Allergy or intolerance to peptides or whole protein
Premature Infant Breast Milk Additives and Formulas • Enfamil Human Milk Fortifier • Similac Human Milk Fortifier • Powdered breast milk additives • Similac Natural Care Advance • Liquid breast milk additive • Similac Special Care Advance • Enfamil Premature +/- Lipil
Premature FormulasGeneral Characteristics compared to Standard • Increased Protein,Vitamins & Minerals • For infants born at <1.5kg • up to 2000-2500gm • Feeding of infants > 2500 gm • risk of vitamin toxicities • Premature formulas vary in nutrient content
“Post” Premature Formulas • NeoSure Advance • EnfaCare Lipil • Standard Dilution: 22 kcal/oz • Protein: between standard and Premature • Vitamins: Higher than standard,significantly lower than Premature • Calcium and Phosphorus: between standard and Premature
Other Specialty Formulas • Portagen (Mead Johnson) • 85% fat MCT, 15% fat Corn oil • Used for infants with chylothorax • Similac PM 60/40(Ross) • Low in Ca, P, K+ and NA; 2:1 Ca:P ratio • Used for infants with Renal Failure • Formulas for Metabolic Disorders • Several condition specific products by Ross and Mead Johnson
Indications • Cow’s milk based • Health term infant • Soy • Vegetarian • Galactosemia • Protein Hydrolysates • Protein intolerance/allergy • other • Preterm Formulas • Post-discharge Preterm formulas • Other Specialty Formulas • Specific medical, metabolic indications
Modification of Infant Formulas • Cost and Availability • Potential mixing errors • Impact on absorbtion, utilization and interaction of nutrients • Evidence Based • Requires detailed assessment to determine need
Products to Augment Energy and Protein in Breast Milk • Human Milk Fortifiers • For Premature infants less than 2000-2500gm only • Standard Infant Formula Powder • 1 teaspoon to 100mL = 24kcal/oz+/- • Do Not Add CHO or Fat w/o protein: Final product is TOO LOW in protein
Finding Up to Date Information • www.ross.com Similac products • www.meadjohnson.com Enfamil products • www.verybestbaby.com Nestle products • www.wyethnutritionals.com generic products • www.brightbeginnings.com lower cost formulas made by Wyeth • www.shsna.com/html/Hypoallergenic.htm Neocate formulas
When Baby is Not Growing • Normal Weight gain and linear growth • Evaluate growth rates (weight, length, OFC) in addition to absolute size (percentiles), body composition, weight/length • Guo et al J Pediatrics 1991
When Baby is Not Growing • Assess Feeding • Number feedings/day • Feeding environment • BF: baby “empties” breasts each feeding • Formula: volume per feeding • Feeding observation
When Baby is Not Growing • Medical status, illness, vomiting, output • Development and behavior • Psychosocial • Diet • Frequency • Amount • Preparation • content
When Baby is not growing • Identify Problem • Address Problem • Formula Changes or modifications • Risk vs benefit • Cost • Availability • Addresses problem
Know What You Are Feeding • Caloric density, protein, fat and carbohydrate vitamin and mineral content. • Osmolality: • Renal Solute Load: Evaluate RSL in context of solute intake, fluid intake and output. • Evidence Based • Rationale • Cost and availability