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Supplementary Figure 2_Van Looy et al. A: UZLX-GIST3 KIT exon 11. B: UZLX-GIST4 KIT exon 11. Control. IMA. BEZ. IMA+BEZ. Control. IMA. BYL. IMA+BYL. Control. IMA. BEZ. IMA+BEZ. Control. IMA. BYL. IMA+BYL. KIT. KIT. pKIT Y719. pKIT Y719. pKIT Y703. pKIT Y703. PI3K.
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Supplementary Figure 2_Van Looy et al. A: UZLX-GIST3 KIT exon 11 B: UZLX-GIST4 KIT exon 11 Control IMA BEZ IMA+BEZ Control IMA BYL IMA+BYL Control IMA BEZ IMA+BEZ Control IMA BYL IMA+BYL KIT KIT pKIT Y719 pKIT Y719 pKIT Y703 pKIT Y703 PI3K PI3K AKT AKT pAKT S473 pAKT S473 MAPK MAPK pMAPK pMAPK Tubulin Tubulin C: UZLX-GIST2 KIT exon 9 D: GIST48 KIT exon 11 + 17 Control IMA BKM IMA+BKM Control IMA BYL IMA+BYL Control IMA BKM IMA+BKM Control IMA BEZ IMA+BEZ KIT KIT KIT pKIT Y719 pKIT Y719 pKIT Y719 pKIT Y703 pKIT Y703 pKIT Y703 PI3K PI3K PI3K AKT AKT AKT pAKT S473 pAKT S473 pAKT S473 MAPK MAPK MAPK pMAPK pMAPK pMAPK Tubulin Tubulin Tubulin