1 / 5

AIMS

Adiponectinemia, glucose status, insulin secretion and insulin resistance in obese women: influence of weight loss. AIMS.

cili
Download Presentation

AIMS

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Adiponectinemia, glucose status, insulin secretion and insulin resistance in obese women:influence of weight loss AIMS 1) To compare variation in adiponectin levels, in insulin secretion / insulin resistance indexes, and in anthropometric parameters in obese women during weight loss program, according to their initial status; 2) To compare metabolic status changes in obese women during weight loss program, according to their initial status; 3) To assess the association between changes in adiponectin levels and changes ininsulin secretion and insulin resistance indexes with those in anthropometric parameters.

  2. METHODS • 100 premenopausal obese women characterized for anthropometric parameters (BMI, waist, WHR, total fat mass) • fasting venous blood sample collection + classic 75g OGTT • one index of insulin resistance: homeostatic model assessment of insulin resistance (HOMA-IR); • one of insulin sensitivity: Matsuda formula; • two insulin secretion indexes: homeostatic model assessment of beta cell (HOMA%beta) and insulinogenic index (INS-i). • Women entered in a weight loss program and were reassessed for all parameters after 6 and 12 months.

  3. RESULTS

  4. RESULTS * Correlation present after adjustment for anthropometric parameters

  5. As expected we demonstrated higher insulin secretion and lower insulin resistance indexes in normoglycemic obese women . • In weight loss programs, obese women lose fat mass (with a subsequently increase in insulin sensitivity and insulin secretion) independently from their initial metabolic status. • Adiponectin levels parallels insulin sensitivity indexes during the process of weight reduction, independently from the amount of fat mass loss. • That might indicate a direct insulin-sensitizing effect of adiponectin.

More Related