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Blueberries… Health Benefits of these Superfruits. Amy Howell, Ph.D. Marucci Center for Blueberry Cranberry Research Rutgers University Chatsworth, NJ. Blueberries Considered one of the healthiest fruits Why? Wide array of diverse phytochemicals Broad portfolio of compelling research
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Blueberries… Health Benefits of these Superfruits Amy Howell, Ph.D. Marucci Center for Blueberry Cranberry Research Rutgers University Chatsworth, NJ
Blueberries • Considered one of the healthiest fruits • Why? • Wide array of diverse phytochemicals • Broad portfolio of compelling research • Communication of the health messages
Blueberries The Original Functional Food • Native to North America • Folklore uses • Wound healing • Blood poisoning • Stomach ailments • Diarrhea • Urinary disorders • Meat preservative What is responsible for these medicinal benefits?
Lutein Zeaxanthin Lycopene Carotene Plant Pigments Coloration Health benefits – Antioxidant, other Carotenoids Anthocyanins >13 in blueberries
Proanthocyanidins “Tannins” Plant defense compounds Predator feeding deterrents Complex molecules Astringent taste Multiple health benefits Antibacterial Antioxidant
Small Fruit Total Flavonoid Content Flavonoids other dry matter mg equivalents/ g dry weight
Damaging molecules called OXIDANTS (Free Radicals) Attack our bodies Like bullets in our blood streams Cause cell damage, disease, aging • Oxidants are made by: • Our own bodies, when cells grow and die • How else are they formed?
Our bodies have natural defenses against OXIDANTS We produce ANTIOXIDANTS to stop damage As we age, our bodies produce fewer natural antioxidants We can get extra antioxidants from eating fruits and vegetables Blueberriesare very high in ANTIOXIDANTS
Antioxidant Activity* Blueberry 22.3 Blackberry 20.4 Garlic 19.4 Strawberry 15.4 Consumer Confusion: Antioxidant level vs. antioxidant activity *Oxygen Radical Absorbance Capacity Source: Ron Prior, U.S.D.A.
Vascular Benefits • Heart Disease • Stroke • Eyesight Stickiness of blood platelets Inflexibility of arteries Inflammation Oxidation of LDL cholesterol
Heart Health Kalt Ag Canada Fed pigs blueberries (1-4 cups human dosage equiv.) and tried to link changes in heart health to levels of plant compounds extracted from tissues of pigs
Blueberry lowered total cholesterol 12% in both studies Worked better when diet included wide range of flavonoids In phytochemical poor diet, blueberries counteracted effects of added cholesterol, sugar and salt
Protection Against Ischemic Stroke by Blueberries Reduced brain damage following release of blood clots during a stroke Sweeney et al., 2002. Nutritional Neuroscience.
Macular Degeneration (study underway) Losso LSU Lose pigment, grow blood vessels Blurs “straight ahead” vision Age-related No effective treatments • Testing whether blueberries can inhibit blood vessel formation and retain pigment levels
Motor and Cognitive Behavior Joseph USDA • Aging – decreased ability to respond to oxidative or inflammatory stressors • Blueberry shown to prevent this and/or restore it by antioxidant and anti-inflammatory activities • Blueberries decreased brain inflammation similar to the pain reliever “Aleve” • May effect genes that turn this on and off
Blueberries and Brain Aging Blueberry Dietary Supplementation Reversed age-related mental decline - Memory loss - Motor behavioral deficits Joseph, J.A. et al. J. Neuroscience. 1999
Improvements in Decision Speed(Human Clinical) (p=0.007) Martin, R. et al., 2002
Alzheimer’s Disease Brain Tangles Brain Plaques As the brain ages, vulnerability to oxidative stress increases – Leads to behavioral deficits Functionality Blueberries enhanced communication between neurons
Blueberry Diet Induces Neurogenesis Blueberry diet Control diet
Antioxidant Effects Anti-inflammatory Effects Alterations in Neuronal Communication (cell signaling) Increased Neurogenesis Many compounds work together to achieve these Blueberries Promote Brain Health - Goes beyond Antioxidant Activity - Mechanisms Involved:
Prevent binding Infection Prevention of Bacterial Adhesion Bacteria bind to cells Colonization Infection Possible role in prevention of urinary tract infections…like cranberry
Health Benefits Due to the Interplay of a Mixture of Complex Molecules Eat the whole fruit!!
How Much is Enough? 1 cup (daily) Fresh or frozen