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Organophosphates and Enzymes

Learn about the impact of organophosphates on the nervous system, specifically inhibiting acetylcholinesterase and causing acetylcholine buildup. Discover the effects of this process and its relevance in neurobiological functions.

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Organophosphates and Enzymes

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  1. Organophosphates and Enzymes

  2. Vocabulary to Know: Review • Neuron: A cell that transmits electrical or chemical signals in the body • Neurotransmitter: A chemical that sends a signal from one neuron to another • Synapse: The connection between neurons where neurotransmitters pass.

  3. Acetylcholine and Acetylcholinesterase • Acetylcholine: A neurotransmitter involved in transmission of signals that regulate muscle stimulation, learning and memory. • Acetylcholinesterase: An enzyme that degrades acetylcholine (substrate). • Why might this be important?

  4. Organophosphate and Enzymes Video

  5. Here’s The Problem • Integumentary System

  6. Here’s The Problem • Circulatory System

  7. Here’s The Problem • Nervous System: Organophosphates enter the brain and inhibit acetylcholinesterase.

  8. Nervous System • With organophosphates around, acetylcholine builds up in the nervous system (parasympathetic and sympathetic) • The build up in the parasympathetic causes the most symptoms. • Bad things happen. • SLUDGE: Overstimulation at the orifices. • Increased saliva, tears, urination, defecation, gastrointestinal problems and vomiting Acetylcholine

  9. Other Non-Competitive Inhibitors • Alzheimer’s disease drugs work this way too. • They “stop up” acetylcholinesterase in order to prevent the breakdown of acetylcholine. This is important for thinking and memory.

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