Letromina Tablets (Generic Letrozole Tablets)

1. Letromina Tablets (Generic Letrozole Tablets) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets (Generic Letrozole Tablets) are used for the adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Letromina is used for the extended adjuvant treatment of early breast cancer in postmenopausal women who have received 5 years of adjuvant tamoxifen therapy. This medicine is also indicated for first-line treatment of postmenopausal women with hormone receptor positive or hormone receptor unknown locally advanced or metastatic breast cancer. Letromina (Generic Letrozole) is also used for the treatment of advanced breast cancer in postmenopausal women with disease progression following antiestrogen therapy. Letrozole (Letromina Tablets ) has also been used off-label for more than 15 years to treat infertility in women with PCOS. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Letromina Tablets (Generic Letrozole Tablets) Active Ingredient The active ingredient contained in Letromina tablets is Letrozole. Each tablet of Letromina contains 2.5 mg of Letrozole. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Letromina Tablets (Generic Letrozole Tablets) Chemical Structure The structure of Letrozole is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Letromina Tablets (Generic Letrozole Tablets) Letromina tablets are manufactured by Alpha Pharma Healthcare Private limited, India in the strength of 2.5 mg. ( Website: https://www.alpha-pharma.com/ https://www.alpha-pharma.com/ ) URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Letromina Tablets (Generic Letrozole Tablets) Letrozole Tablets – Brand Names Letrozole tablets are available under various drug trade names that include Femara, Letromina, Fertolet, Letoval, Letroz, Letov, Herhope, Letocor, Lets, Letshil, Lutrozole, Oncolet, and Stimufol. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Letromina Tablets (Generic Letrozole Tablets) Uses of Letromina Tablets Letromina tablets manufactured by Alpha-Pharma Healthcare Pvt. Ltd., India is used for the treatment of breast cancer in post- menopausal women (i.e. women who no longer have periods). Letromina is used for adjuvant treatment of postmenopausal women with hormone receptor positive early breast cancer. Extended adjuvant treatment of postmenopausal women with early breast cancer who have received prior standard adjuvant Tamoxifen therapy. First and second-line treatment of postmenopausal women with hormone receptor positive or unknown advanced breast cancer. The safety and efficacy of Letrozole has not been demonstrated in the neoadjuvant treatment of breast cancer. Letrozole is not indicated in hormone receptor negative disease. URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Letromina Tablets (Generic Letrozole Tablets) Uses of Letromina Tablets Letrozole (Generic Letromina tablets), an aromatase inhibitor, has been demonstrated to be effective as an ovulation induction and controlled ovarian hyperstimulation agent in infertile women with Anovulatory Infertility. For this use, you'll take Letrozole tablets for a few days after the start of your period. However, dose administration has generally been limited to 5 days at 2.5 to 7.5 mg daily. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Dosage The dosage of Letromina Tablets Letromina Tablets (Generic Letrozole Tablets) is given below: Breast Cancer: The recommended dose is 2.5 mg once daily. Treatment should continue as long as tumour response is seen. Patients with cirrhosis or severe hepatic impairment: 2.5 mg every other day. The drug should be discontinued if tumour stops responding as judged by tumour progression. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Dosage The dosage of Letromina Tablets Letromina Tablets (Generic Letrozole Tablets) is given below: Dosage For Infertility: The usual dosage of Letromina Tablets (Generic Letrozole Tablets) for inducing ovulation is 2.5 mg taken by mouth once daily for 5 days. Your doctor may ask you to start taking the medicine either on day 3 or day 5 of your menstrual cycle. (Day 1 of your menstrual cycle is the first day of your period.) If you’re not having periods when starting Letrozole, your doctor will recommend when you should start taking the medicine. Sometimes your doctor may recommend that you take a higher dosage of Letromina, such as 5 mg or 7.5 mg daily for 5 days. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Contraindications Letromina is contraindicated in patients with a hypersensitivity to Letrozole, other aromatase inhibitors, or any other component of this medication. Letromina tablets are also contraindicated in cases of Pregnancy, Lactation, patients with severe hepatic dysfunction, in the presence of an ovarian cyst, except polycystic ovary, since further enlargement of the cyst may occur. Letromina must not be administed to patients with abnormal uterine bleeding of undetermined origin and patients with uncontrolled thyroid or adrenal dysfunction or in the presence of an organic intracranial lesion such as pituitary tumour. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Letromina Tablets (Generic Letrozole Tablets) Storage Instructions Letromina Tablets (Generic Letrozole Tablets) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Letromina Tablets (Generic Letrozole Tablets) Warnings In patients with severe hepatic cirrhosis (Child-Pugh score C), systemic exposure and terminal half-life were approximately doubled compared to healthy volunteers. Such patients should therefore be kept under close supervision. Repeat dose toxicity studies of up to 12 months duration conducted on rats and dogs have reported no-effect levels for Letrozole, but changes were observed at the lowest doses used (0.03 mg/kg/day). Letrozole did not show evidence of genotoxicity in in vitro assays for gene mutations and in vitro and in vivo assays for chromosomal damage. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Letromina Tablets (Generic Letrozole Tablets) Warnings A reported 104 week carcinogenicity study with oral doses of Letrozole at 0.1, 1 or 10 mg/kg/day in rats showed an increased development of ovarian benign gonadal stromal tumours at the highest dose (approximately 400 times human exposure at the maximum recommended clinical dose). Osteoporosis and/or bone fractures have been reported with the use of Letrozole tablets. Therefore monitoring of overall bone health is recommended during treatment. Embryo-Fetal toxicity: Can cause fetal harm when administered to pregnant women. Obtain a pregnancy test in females of reproductive potential. Advise females of reproductive potential to use effective contraception. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets (Letrozole) and Alcohol Letrozole (Letromina Tablets) can cause side effects similar to menopausal symptoms, like hot flashes, night sweats, and headaches. Try to avoid alcohol, caffeine, or smoking, because they can worsen these symptoms. If you drink alcohol while you’re taking Letrozole (Letromina Tablets), you might be more likely to have certain side effects, including: headache, feeling weak or having increased tiredness, dizziness, flushing (temporary warmth, redness, or deepening of skin color) If you plan to drink alcohol while you’re taking Letrozole, make sure to talk with your doctor. They can recommend if there’s an amount that’s safe for you. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Side Effects The most common Letrozole (Letromina Tablets) side effects with an incidence rate greater than 20% were hot flashes, arthralgia, flushing, asthenia, edema, arthralgia, headache, dizziness, hypercholesterolemia, sweating increased, bone pain and musculoskeletal. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Overdose Isolated cases of Letrozole (Letromina tablets) overdose have been reported. In these instances, the highest single dose ingested was 62.5 mg or 25 tablets. While no serious adverse reactions were reported in these cases, because of the limited data available, no firm recommendations for treatment can be made. However, emesis could be induced if the patient is alert. In general, supportive care and frequent monitoring of vital signs are also appropriate. In single-dose studies, the highest dose used was 30 mg, which was well tolerated; in multiple-dose trials, the largest dose of 10 mg was well tolerated. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets During Pregnancy Letrozole Tablets (Letromina) has been classified by the US FDA as Pregnancy Category D. Based on postmarketing reports, findings from animal studies and the mechanism of action, Letrozole tablets (Letromina) can cause fetal harm and is contraindicated for use in pregnant women. In post-marketing reports, use of Letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects; however, the data are insufficient to inform a drug-associated risk. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets During Nursing Letromina tablets (Letrozole) are contraindicated in breast feeding women. It is not known if Letrozole is excreted in human milk. There are no data on the effects of Letrozole on the breastfed child or the effects of Letrozole on milk production, however, exposure of Letrozole in lactating rats led to impaired fertility of male offspring. Because of the potential for serious adverse reactions in breastfed infants from Letrozole, advise lactating women not to breastfeed while taking Letromina tablets (Letrozole) and for at least 3 weeks after the last dose. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Letromina Tablets (Generic Letrozole Tablets) Letromina Tablets Letromina Tablets (Generic Letrozole Tablets) by Alpha Pharma Healthcare Private limited, India. URL: URL: https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html https://www.clearskypharmacy.biz/generic-femara-letromina-by-alpha-pharma.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )