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End-replication problem

End-replication problem. Repetición telomérica : TTAGGG. Mecanismo de acción de la telomerasa. Extremo 3´ DNA telomérico. Actividad de telomerasa: Ensayo TRAP. Actividad de telomerasa: Ensayo TRAP. Límite de Hayflick. Determinación del largo del telómero.

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End-replication problem

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  1. End-replication problem

  2. Repetición telomérica: TTAGGG

  3. Mecanismo de acción de la telomerasa

  4. Extremo 3´ DNA telomérico

  5. Actividad de telomerasa: Ensayo TRAP

  6. Actividad de telomerasa: Ensayo TRAP

  7. Límite de Hayflick

  8. Determinación del largo del telómero

  9. Reducción telómerica en sucesivas generaciones

  10. Estabilización del telómero por la telomerasa

  11. Cancer and telomerase What price immortality?

  12. Blasco (2005) Nature Reviews Genetics6, 611-622

  13. Extensión de la vida de células somáticas por expresión de telomerasa

  14. ¿Qué pasa con estos ratones? • mRT -/- • p16INK4a -/- ; ARF -/- • mRT -/- ; p16INK4a -/- ; ARF -/- • p53 -/- • p53 -/- ; mRT -/-

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