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Development of pharyn geal apparatus : pharyngeal arches and its derivatives

Development of pharyn geal apparatus : pharyngeal arches and its derivatives. Dr. N a ndor Nagy. Semmelweis University. Pharyngeal (or branchial) arches form in craniocaudal sequence during 4th to 5th weeks. Structures in embryonic pharyngeal arches reorganize

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Development of pharyn geal apparatus : pharyngeal arches and its derivatives

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  1. Development of pharyngeal apparatus: pharyngeal arches and its derivatives Dr. Nandor Nagy Semmelweis University

  2. Pharyngeal (or branchial) arches form in craniocaudal sequence during 4th to 5th weeks Structures in embryonic pharyngeal arches reorganize to form cartilages, nerve, muscles & arteries in fetus

  3. In humans, five pairs of pharyngeal arches form on either side of the pharyngeal foregut, starting on day 22. • Each arch has an outer covering of ectoderm, an inner covering of endoderm, and a core of mesenchyme derived from paraxial and lateral plate mesoderm and neural crest cell-derived ectomesenchyme.

  4. Pharyngeal pharyngeal

  5. Neural crest derived mesenchyme fill the pharyngeal arches

  6. The HOX and Dlx code provides spatial identity to crest cells colonizing pharyngeal arches.

  7. 6

  8. Muscles of arches

  9. 6 5) Sixth Arch

  10. Recurrent laryngeal nerve and

  11. -The1st pharyngealcleftformstheexternalauditorymeatus. -Thesecondpharyngealarchexpands and fuseswiththecardiaceminencetocovertheremainingpharyngealclefts.

  12. Brachial pouches: outpocketings of pharynx endoderm E. Pouch 5: C-cells (produce calcitonin)

  13. ***trapezius and sternocleidomastoid muscles arise from the caudal 6th pharyngeal arch, • and these muscles receive motor innervation via the XI Cranial Nerve(Spinal Accessory Nerve)

  14. Abnormal development of pharyngeal arches -aplasia of thymus and parathyroid gland -TBx1----FGF8 1:3-4000

  15. The pharyngeal pouches contain the primordia of a number of different adult structures

  16. Tonguedevelopment Lingual musculature stems from muscle cells that immigrate from the occipital somitesinto the tongue. The emigrating predecessor cells follow the hypoglossal nerve (CN 12). Innervation of the tongue

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