Social function: Global Assessment of Function Scale * *

1. BioPsychology Research Group, Psychiatry Clinics, University of Duisburg-Essen, D-45147 Essen (1), Eggers-Foundation, Alexanderstraße 23, D-45130 Essen (2) Evaluation of two years of residential care treatment for early-onset schizophreniawww.eggers-stiftung.de / www.biopsychology.uni-essen.deM. J. Hemmerle1,2, B. Röpcke1,2, C. Eggers1,2, R. D. Oades1m.hemmerle@eggers-stiftung.de Sample: Trialogue: 12 Trialogue residents with 2 years of intensive care Diagnosis: 10 Schizophrenic disorder (ICD-10: F20); 2 Schizoaffective disorder (ICD-10: F25) Assessment time points: T1: On entry to Trialogue T3: When leaving Trialogue Comparison Group: 12 adolescents admitted consecutively to the clinic with Early Onset Schizophrenia (EOS: ICD-10: F20) Assessment time points: T1: At discharge T3: Catamnesis after 3 years Selection towards more impaired patients for Trialogue: More re-admissions, more restricted socioeconomic resources, more co-morbid disorders, more impaired neuropsychological performance, longer duration of untreated psychosis (reflecting more insidious onset) • Methods and results: • Positive and Negative Syndrome Scale (PANSS) & Scales for the Assessment of Negative/Positive Symptoms (SANS & SAPS)** • Global Assessment of Function Scale (GAF)** • Clinical Global Impression (CGI)** • Manchester Short Assessment of the Quality of Life (MANSA, German version) [see example in figure below] • Hamburg-Wechsler Intelligence Test for adults /revised (HAWIE-R) (Information, Arithmetic, Digit-Symbol-Test T*, Block-design*, Digit Span) • Trail Making Test (TMT-A*, -B T*) • Word Fluency (FAS)* • Wechsler Memory Scale-Revised • (WMS-R, delayed reproduction**) • *: Significant improvement of Trialogue (p < .05) • T: Trend (p < .1) • *: Significant interaction of groups and assessments showing an advantage of Trialogue (p < .05) • T: Trend (p < .1) • T R I A L O G U E • Provides pedagogic – therapeutic intensive care residential group for adolescents and young adults suffering from schizophrenia • Integrate communication: "family-patient-professional"-Trialogue • Community centred • 8 residents • Multi-professional Team • Close co-operation with psychiatric Clinic • Ratio nurse/affected 1:1 • 24 hours attendance • Residence limited to 2 years Psychopathology: PANSS/SANS & SAPS** Negative Symptoms Positive Symptoms Social function: Global Assessment of Function Scale** Quality of live: Subjective contentedness with relations to family* content Not content Neuropsychology: Estimated effects and 95% confidence bounds of AOS reference values (Hedges´ unbiased g) Residential Conditions at T3* Summary and Conclusions Implementation of community centred intense early care of EOS patients over 2 years is effective at improving function in psychopathological, social, and neuropsychological areas of function at the time the patients leave. Special residential care for a limited time can be recommended, especially for those who do not find regular activity following clinical discharge. Such a programme should ideally be associated with special educational facilities and linked to early detection and treatment centres. Regular activity at T3*