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What is the neurophysiological substrate of memory?

What is the neurophysiological substrate of memory?. Two studies looking at long-term neural changes associated with behavior in Motor tasks Running, Reaching task (Primary motor cortex) Sensory tasks Enriched environment barrel cortex.

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What is the neurophysiological substrate of memory?

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  1. What is the neurophysiological substrate of memory? • Two studies looking at long-term neural changes associated with behavior in • Motor tasks • Running, Reaching task • (Primary motor cortex) • Sensory tasks • Enriched environment • barrel cortex

  2. Motor learning and novel sensory experience promote rapid dendritic spine formation

  3. Enhanced spine dynamics during adolescent motor training is region- and learning-specific.

  4. A fraction of newly formed spines persists over weeks and correlates with performance after learning.

  5. Novel experience promotes spine elimination. .

  6. Maintenance of daily formed new spines and spines formed during early development throughout life.

  7. Spine maintenance in different cell types and cortical layers.

  8. Summary • New experiences lead to the fast (within 1 hour) formation of new dendritic spines in brain areas used to perform new behavior • The number of remaining new spines formed during the new experiences predicts the success of newly acquired behaviors. • Pruning increases after new spine formation to bring back total number of spines to baseline level. • The remaining spines appear to last long enough to sustain memory across a lifetime.

  9. How applicable are these studies to humans? • Humans have several types of long-term memory • Implicit: Procedural, classical, priming • Explicit: consciously accessed memory, declarative and semantic

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