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4000. 2000. 0. 1. 2. 4. 8. 12. 0. T max (h). -2000. Predicted AUC 0-24 - Observed AUC 0-24 (ngh/mL). -4000. r = -0.164 P = 0.276. -6000. -8000. -10000.

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-10000

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  1. 4000 2000 0 1 2 4 8 12 0 Tmax (h) -2000 Predicted AUC0-24 - Observed AUC0-24 (ngh/mL) -4000 r = -0.164 P = 0.276 -6000 -8000 -10000 Correlation of the prediction error (predicted AUC0-24 – observed AUC0-24) and time required to reach the peak concentration (Tmax) Supplemental Fig. 1

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