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Eric Niederhoffer SIU-SOM

A 4-year-old African boy is brought in by his adoptive parents who say that he has pain in his limbs and does not want to walk. A 40-year- old man complains of progressive exertional shortness of breath. How are CO 2 , NO, and O 2 processed and transported?. How is heme synthesized?.

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Eric Niederhoffer SIU-SOM

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  1. A 4-year-old African boy is brought in by his adoptive parents who say that he has pain in his limbs and does not want to walk A 40-year-old man complains of progressive exertional shortness of breath How are CO2, NO, and O2 processed and transported? How is heme synthesized? Eric Niederhoffer SIU-SOM

  2. CO2 processing and transport carbonic anhydrase, anion exchanger, carbamate formation, Bohr effect NOprocessing and transport glutathione O2 processing and transport hemoglobin/myoglobin structure, allostery, cooperativity Heme synthesis pathway, disorders Small Molecule Processing and Transport

  3. CO2 Processing and Transport CO2 CO2 H2O HbNH2 from tissues CA H2CO3 + Hb(O2)4 + H+ + HbNH-CO2- Cl- Cl- AE1 HCO3- HCO3- + H+Hb + O2 O2 plasma to tissues CO2 CO2 H2O HbNH2 to air CA H2CO3 + Hb(O2)4 + H+ + HbNH-CO2- Cl- Cl- AE1 HCO3- HCO3- + H+Hb + O2 O2 plasma from air

  4. NO Processing and Transport http://www.comprehensivephysiology.com/WileyCDA/CompPhysArticle/refId-c090009.html

  5. Hemoglobin Structure Changes http://www.mfi.ku.dk/PPaulev/chapter8/images/8-3.jpg

  6. Factors Affecting Binding of O2 Depends on pH ([H+]), CO2, BPG, Temp

  7. Factors Affecting Binding of O2 Adaptation Figures from http://www.wiley.com/college/voet/047119350X/image_gallery/ch10/index.html

  8. Heme Synthesis mit SCoA + Gly 5AS PBGS PBG 5ALA PBGD Heme HMB FC UPGIIIS PPIX UPGIII UPGIIIDC PPGO CPGO CPGIII PPGIX

  9. How are CO2 and NO processed and transported? How are myoglobin and hemoglobin similar and different? What portion of hemoglobin is involved in small molecule transport? What allosteric effectors bind hemoglobin? How do allosteric effectors produce left and right shifts of the hemoglobin-O2 binding curves? How is heme synthesized? How is heme synthesis regulated? Review Questions

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