human cardiac stromal cells

1. The Physiological Function of Human Cardiac Stromal Cells ◆ supporting and arranging Human Cardiac Stromal Cells, maintaining the normal structure of myocardium. ◆ surrounded by Human Cardiac Stromal Cells, to prevent the Human Cardiac Stromal Cells overextension and fracture. ◆ Assist the transfer of contractile force between Human Cardiac Stromal Cells. ◆ reserve energy for the Human Cardiac Stromal Cells in the next cardiac cycle to stretch. In addition to the above role, recent studies have proved that it is the determinant of myocardial hardness. Myocardial tissue consists of Human Cardiac Stromal Cells and interstitial cells. Human Cardiac Stromal Cells account for about 75% of the volume of myocardial tissue, among which the interstitial tissue only accounts for 25% of the volume of myocardial tissue, but the number ofHuman Cardiac Stromal Cells is twice that of Human Cardiac Stromal Cells, including endothelial cells, vascular smooth muscle cells and fibroblasts.According to the distribution and function of collagen in myocardium, it can be divided into interstitial collagen, basal membrane collagen and extracellular collagen, among which interstitial collagen is the main type. Myocardial interstitial collagen is composed of collagen type I ~ VI, mainly for type I (80%) and Ⅲ type (11%), collagen, is secreted by fibroblast synthesis;In addition, small amounts of type IV and V are secreted by fibroblasts and cardiomyocytes.Type VI collagen is synthesized by fibroblasts and endothelial cells.Under physiological conditions, collagen renewal is very slow with a half-life of 80-120 days, but collagen degradation is significantly accelerated when tissue is rapidly reconstructed. The growth of Human Cardiac Stromal Cells and interstitial cells have their own regulatory mechanisms, which are independent of each other. The proliferation of Human Cardiac Stromal Cells may not be accompanied by the proliferation of interstitial cells, and the proliferation of interstitial cells may not be accompanied by the hypertrophy of Human Cardiac Stromal Cells, but these two parts are regulated by the hormones of growth factors.Cardiac hypertrophy is a response of cardiac myocytes and cardiac interstitial cells to hormones and growth factors. The

2. combination of these pro-cardiac hypertrophy factors with the receptor causes conformational changes of the receptor, activates the corresponding protein kinase, and phosphorylates some specific transcription factors, so as to transmit the growth factor signal to the nucleus, regulate gene expression at the transcription level, and generate the response of cardiac myocytes and interstitial cells. About Creative Bioarray Creative Bioarray is an innovative biotechnology company whose mission focuses on developing unique technologies that provide global scientists with high quality products and satisfactory services to facilitate the investigation of life science researches. We provide a wide range of high quality normal human and animal cells, cell culture medium and reagents, FISH probes, tissue arrays, microorganisms and equipments. In addition, we also offer series of related services including cell services, biosample services and histology services for the researcher to make their project better and faster.