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Calcium Cycling in Cardiac Cells

Calcium Cycling in Cardiac Cells. Lin Guo-hua. Cardiac E-C coupling. Slow or L-type Ca 2+ Channels (DHPRs). L-type Ca 2+ Channels. Ca 2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor). cardiac ryanodin receptor. Physiological and pathophysiological regulation.

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Calcium Cycling in Cardiac Cells

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  1. Calcium Cycling in Cardiac Cells Lin Guo-hua

  2. Cardiac E-C coupling

  3. Slow or L-type Ca2+ Channels (DHPRs)

  4. L-type Ca2+ Channels

  5. Ca2+ Release Channel of the Sarcoplasmic Reticulum (Ryanodine Receptor)

  6. cardiac ryanodin receptor

  7. Physiological and pathophysiological regulation

  8. Ca2+ Pump of the Sarcoplasmic Reticulum (SERCA)

  9. SERCA

  10. SERCA-PLN complex

  11. Phospholamban (PLN) & Sarcolipin (SLN)

  12. The Ca2+ Pump of the PlasmaMembrane (PMCA)

  13. Sodium/Calcium Exchanger (NCX)

  14. Troponin C (TnC)

  15. Calmodulin (CaM)

  16. Calmodulin (CaM) &Calmodulin Kinase II (CaMKII)

  17. Calmodulin Kinase II (CaMKII)

  18. Regulation of Ca Transporters by CaM and CaMKII

  19. frequency-dependent acceleration of relaxation (FDAR)

  20. Calsequestrin (CSQ)

  21. Organization of EC coupling elements

  22. Integrative Analysis of Calcium Cycling in Cardiac Muscle

  23. [Ca2+]i Transient in Heart Cell

  24. [Ca2+]i sparks & [Ca2+]I Transient

  25. Ca2+ Requirements for Activation of Myofilaments

  26. Autoregulation of SR Ca2+ Content

  27. Modulation of the RyR Changes of sarcolemmal fluxes and SR CaCa2+ release during potentiation of CICR by caffeine (500 mmol/L)

  28. relationships between the various Ca2+ fluxes

  29. Ca2+ Influx During the Cardiac AP

  30. Ca2+ Removal From the Cytosol DuringCardiac Relaxation

  31. Frequency-dependent changes in the fraction of Ca release that is taken back up by the SR

  32. Measurement of SR Ca2+ content and forcefrequency relationship.

  33. force frequency relation

  34. Frequency-dependence of isometric twitch force (twitch) and rapid cooling contractures (RCC) in nonfailing and failing human myocardium

  35. Relationship between NCX and SERCA protein levels and in non-failing and failing human myocardium

  36. Caffeine contractures in isolated rabbit myocytes following adenoviral gene transfer of LacZ and NCX

  37. Frequency-dependent changes in twitch force, aequorin light signals RCCs in huma atrial muscles (A) and ventricular muscles (B).

  38. Steady-state twitches, postrest twitches, and RCCs in isolated human atrial myocardium.

  39. Rapid Cooling Contracture

  40. Paired RCCs and Ca2+Reuptake Into the SR

  41. postrest potentiation & postrest decay Rest-dependent changes in the amplitudes of twitch force and RCCs) in human atrial myocardium (A) and ventricular muscles (B)

  42. restitution postextrasystolic potentiation

  43. Ca2+ Restitution of the Ca transient

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