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BMP Family

An overview of BMP family, members of BMP family, cellular function, and role in diseases.t<br>https://www.creative-diagnostics.com/bmp-family.htm<br>

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BMP Family

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  1. BMP Family Overview Bone morphogenetic proteins ( BMPs ) are a group of growth factors also known as cytokines and as metabologens. BMPs are secreted signaling molecules that belong to the transforming growth factor β family of growth and differentiation factors. Bone morphogenetic proteins are synthesized as large precursors consisting of a signal peptide, a prodomain and a carboxy terminal region of 100 to 125 amino acids. Within the carboxy terminal region of most bone morphogenetic ptoteins are seven highly conserved cysteine residues important for correct folding of these dimeric molecules.Bone morphogenetic protein receptors are members of a larger family of serine threonine kinases that include the receptors for transforming growth factor vetas, activins and inhibins. Members of BMP Family Originally, seven such proteins were discovered. Of these, six (BMP2 through BMP7) belong to the transforming growth factor beta superfamily of proteins. BMP1 is a metalloprotease. Since then, thirteen more BMPs have been discovered, bringing the total to twenty. Table 1. BMP family related products BMP1 BMP1b BMP2 BMP2A BMP2B BMP3 BMP Ligands BMP4 BMP5 BMP6 BMP7 BMP8A BMP8B

  2. BMP Receptor BMPR1A BMPR1B BMPR2 BMP1  Bone morphogenetic protein 1, also known as BMP1, is a protein which in humans is encoded by the BMP1 gene. BMP-1 is implicated in de novo endochon- dral bone formation and is also a met- alloprotease with multiple sites for potential N-linked glycosylation and EGF-like se- quences that may confer calcium depen- dence on binding activities of adjacent CUB domains. Figure 1. Crystal Structure of BMP1 Protease Domain. BMP2  Bone morphogenetic protein 2 or BMP-2 belongs to the TGF-β superfamily of proteins. Like many other proteins from the BMP family, BMP-2 has been demonstrated to potently induce osteoblast differentiation in a variety of cell types. It is involved in the hedgehog pathway, TGF beta signaling pathway, and in cytokine-cytokine receptor interaction. It is also involved in cardiac cell differentiation and epithelial to mesenchymal transition. https://www.creative-diagnostics.com/bmp-family.htm

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