Notch Family

1. Notch Family Overview Notch proteins are a family of type-1 transmembrane proteins that form a core component of the notch signaling pathway, which is highly conserved in metazoans. Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Notch receptors are single-pass, transmembrane proteins conserved from C.elegans to humans. In vertebrates there are four known notch receptors: notch1, notch2, notch3 and notch4. Notch receptors are heterodimeric proteins, consisting of a large, modular N-terminal extracellular portion non-covalently bound to a transmembrane domain, followed by an intracellular, C-terminal portion. Figure 1. Structure of a Prototype LNR Module from Human Notch1. Members of Notch family Table 1. Notch family related products Notch Receptors NOTCH1 NOTCH2 NOTCH3

2. NOTCH4 Notch 1  Notch homolog 1, translocation-associated (Drosophila), also known as NOTCH1, is a human gene encoding a single-pass transmembrane receptor. This gene encodes a member of the Notch family. Notch 1, when activated before birth, induces radial glia differentiation, but postnatally induces the differentiation into astrocytes. One study shows that Notch-1 cascade is activated by Reelin in an unidentified way. Reelin and Notch1 cooperate in the development of the dentate gyrus, according to another. Notch 2  Neurogenic locus notch homolog protein 2 also known as notch 2 is a protein that in humans is encoded by the NOTCH2 gene. Notch 2 is a member of the notch family. Notch 2 is associated with Alagille syndrome and Hajdu–Cheney syndrome. Mutations within the last coding exon of Notch 2 that remove the PEST domain and escape the nonsense-mediated mRNA decay have been shown to be the main cause of the Hajdu-Cheney syndrome. Figure 2. Structure of the Notch2 protein. https://www.creative-diagnostics.com/notch-family.htm