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HCV Testing trends. General remarks on HCV testing Trends in HCV testing in NI An 11 year dataset RAGS- blood lab initiative- 2011-2012. 80% develop chronic infection. HCV infections. 20% clear infection. `. Antibody positive PCR positive. Current infection. Past infection.
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General remarks on HCV testing • Trends in HCV testing in NI • An 11 year dataset • RAGS- blood lab initiative- 2011-2012
80% develop chronic infection HCV infections 20% clear infection `
Antibody positive PCR positive Current infection Past infection Antibody positive high level PCR negative ` ? Past infection OR Spurious antibody Antibody positive low level PCR negative `
HCV Antibody tests are less perfect than HIV tests • Low antibody positive PCR negative • ?past infection • Or • ?Spurious • E.g fertility occ health etc
Screening EIA (Abbott Architect) Negative Reactive <3 Reactive >3 Monolisa Ag/Ab Monolisa Ag/Ab Negative Positive See next slide HCV Antigen Negative Positive Report: No current infection. Either past infection or false positive antibody. Report: Current infection. Ask for second specimenfor PCR & genotype. Suggest referral. Report: Negative Report: Negative
Screening EIA (Abbott Architect) Reactive >3 Monolisa Ag/Ab Negative Positive PCR Negative Positive Report:No current infection. Indicates past infection. Ask for second specimen Report: Current infection. Ask for second specimenfor PCR & genotype. Suggest referral. Report: Negative
An estimated five out of every six UK people with chronic HCV are unaware of their infection. (2004) Diagnosed Undiagnosed
9.6% of HCV tests
15.4% Of HCV tests
5.2% of HCV tests
25.6 % of HCV tests
0.49 % of HCV tests
0.39 % of HCV tests
Trust positivity rate • 0.21% • GP positivity rate • 0.77% • Addiction positivity rate • 2.4% • Prison positivity rate • 2.0%
Virology testing in NI • Blood lab initiative (2011 2012) Biochemistry Haematology Immunology Microbiology serology (including Virology) Molecular
The blood lab:RAGS • Short term • Uncertainty • Diffs • Longer term • Sustains virology molecular • Better TAT • Scaleable