1 / 18

Course title :Hematology (1)

Course title :Hematology (1). Course code :MLHE-201 Supervisor : Prof.Dr Magda Sultan . Date : 5 / 12 / 2013 Outcome : The student will know : The definition of iron deficiency anemia The diagnosis of iron deficiency anemia . Iron Deficiency Anaemia.

cwen
Download Presentation

Course title :Hematology (1)

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Course title :Hematology (1) Course code :MLHE-201 Supervisor :Prof.DrMagda Sultan . Date : 5/ 12 / 2013 Outcome : The student will know : The definition of iron deficiency anemia The diagnosis of iron deficiency anemia

  2. Iron Deficiency Anaemia

  3. Iron is required for haemoglobin synthesis. • Iron deficiency anaemia develops when the supply of iron is insuficient for the requirements of Hb synthesis .

  4. IRON METABOLISM • ABSORPTION IN DUODENUM • TRANSFERRIN TRANSPORTS IRON TO THE CELLS • FERRITIN AND HEMOSYDERIN STORE IRON 10% of daily iron is absorbed

  5. The macrophages of the reticuloendotelial system store iron released from hemoglobin as ferritin and hemosiderin • Small loss of iron each day in urine, faeces, skin and nails and in menstruating females as blood (1-2 mg daily) • Most body iron is present in hemoglobin in circulating red cells

  6. IRON METABOLISM • Iron concentration (Fe) • N: 50-150 g/dl • Total Iron Binding Capacity • N: 250-450 g/dl • Transferrin saturation • Transferrin receptor concentration • Ferritin concentration • N: 50-300 g/l

  7. IRON DEFICIENCY ANEMIA • ETIOLOGY: • CHRONIC BLEEDING • MENORRHAGIA • PEPTIC ULCER • STOMACH CANCER • ULCERATIVE COLITIS • INTESTINAL CANCER • HAEMORRHOIDS • DECREASED IRON INTAKE • INCREASED IRON REQUIRMENT (JUVENILE AGE, PREGNANCY, LACTATION)

  8. IRON DEFICENCY - STAGES • Prelatent • reduction in iron stores without reduced serum iron levels • Hb (N), MCV (N), iron absorption (), transferin saturation (N), serum ferritin (), marrow iron () • Latent • iron stores are exhausted, but the blood hemoglobin level remains normal • Hb (N), MCV (N), TIBC (), serum ferritin (), transferrin saturation (), marrow iron (absent) • Iron deficiency anemia • blood hemoglobin concentration falls below the lower limit of normal • Hb (), MCV (), TIBC (), serum ferritin (), transferrin saturation (), marrow iron (absent)

  9. IRON DEFICIENCY ANEMIA • GENERAL ANEMIA’S SYMPTOMS: • FATIGABILITY • DIZZENES • HEADACHE • IRRITABILITY • PALPITATION

  10. CHARACTERISTICS SYMPTOMS • GLOSSITIS, STOMATITIS • DYSPHAGIA ( Plummer-Vinson syndrome) • ATROPHIC GASTRITIS • DRY, PALE SKIN • SPOON SHAPED NAILS, KOILONYCHIA, • BLUE SCLERAE • HAIR LOSS • PICA (APETITE FOR NON FOOD SUBSTANCES SUCH AS AN ICE, CLAY) • SPLENOMEGALY (10%) • INCREASED PLATELET COUNT

  11. IRON DEFICIENCY ANEMIA • MCV • MCH • MCHC Nor • Fe • TIBC • TRANSFERIN SATURATION • FERRITIN

  12. BLOOD AND BONE MARROW SMEAR • BLOOD: • microcytosis, hypochromia, anisocytosis,poikilocytosis • BONE MARROW • high cellularity • mild to moderate erythroid hyperplasia (25-35%; N 16 – 18%) • polychromatic and pyknotic cytoplasm of erythroblasts is vacuolated and irregular in outline (micronormoblasticerythropoiesis) • absence of stainable iron

  13. Training Questions : 1.Define iron deficiency anemia 2.How to diagnose iron deficiency anemia ? Reference book : • Essential haematology • Dacie

More Related