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Chapter 8 (part2)

Chapter 8 (part2). Carbohydrates: oligo- and polysaccharides. Glycosidic Linkage. Disaccharides. cellobiose. maltose. (a -D-glucosyl-(1->4)- b -D-glucopyranose). (b -D-glucosyl-(1->4)- b -D-glucopyranose). lactose. sucrose. (b -D-galactosyl-(1->4)- b -D-glucopyranose).

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Chapter 8 (part2)

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  1. Chapter 8 (part2) Carbohydrates: oligo- and polysaccharides

  2. Glycosidic Linkage

  3. Disaccharides cellobiose maltose (a-D-glucosyl-(1->4)-b-D-glucopyranose) (b-D-glucosyl-(1->4)-b-D-glucopyranose) lactose sucrose (b-D-galactosyl-(1->4)-b-D-glucopyranose) (a-D-glucosyl-(1->2)-b-D-fructofuranose)

  4. Higher Oligosaccharides

  5. Oligosaccharide groups are incorporated in to many drug structures

  6. Polysaccharides

  7. Amylose and Amylopectin

  8. Iodine binding to starch

  9. glycogen

  10. Dextrans

  11. Cellulose

  12. Cellulose vs Amylose amylose cellulose Glucose units rotated 180o relative to next residue

  13. Cellulose

  14. Chitin

  15. Chitin vs Cellulose

  16. Glycoproteins

  17. O-linked Glycoproteins

  18. Blood ABO Antigens Structure of the ABO blood group carbohydrates,R represents the linkage to protein in the secreted forms, sphingolipid in the cell-surface bound form open square = GlcNAc, open diamond = galactose, filled square = fucose, filled diamond = GalNAc, filled diamond = sialic acid (NANA)

  19. N-linked Glycoproteins

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