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ADAPT Update

ADAPT Update. AfriCan Forum Entebbe, 17-19 January 2013. A African D Development of A AIDS P Prevention T Trials Capacity. Goal of ADAPT: Build local capacity so that Africans can plan, conduct and analyse large scale, multi-centred AIDS prevention trials.

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ADAPT Update

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  1. ADAPT Update AfriCan Forum Entebbe, 17-19 January 2013

  2. A African D Development of A AIDS P Prevention T Trials Capacity

  3. Goal of ADAPT: Build local capacity so that Africans can plan, conduct and analyse large scale, multi-centred AIDS prevention trials

  4. Lack of prevention evidence from RCTs More than 6000 HIV prevention studies published between 2000 and end of 2012 Less than 300 were RCTs

  5. Lack of African involvement

  6. Lack of African involvement

  7. Second phase First phase 2007-2009 2010-2014

  8. ADAPT training

  9. First course participants • 23 researchers from 11 African countries • Botswana, Lesotho, Malawi, Mozambique, Namibia, Nigeria, South Africa, Swaziland, Tanzania, Zambia, Zimbabwe • From government (via NAAs), universities, and NGOs

  10. Where are they now?

  11. Left HIV prevention work and joined a bank Moved from NGO to National AIDS Authority Prominent in National AIDS Authorities Elected – became Minister – NAA in remit With CIET in Nigeria – on faculty for next course Head of department in University Promoted within research organisation Post-doctoral fellowship Completing MSc Epidemiology and Statistics Coordinating CIET work in Botswana

  12. ADAPT presentations at AIDS impact conference Who has multiple concurrent sexual partnerships in Botswana? Results of a national cross sectional survey. Laetsang D, Ho-Foster A, Masisi M, Anderson M, Tlhoiwe D, Cockcroft A, Andersson N Community views of inter-generational sex: findings from focus groups in Botswana, Namibia and Swaziland. Kunda JL, Kgakole L, Cockcroft A, Masisi M, Laetsang D, Ho-Foster A, Marokoane N, Andersson N Characteristics and attitudes of the choice-disabled in Namibia. Van Rooy G, Mitchell S, Masisi M, Cockcroft A, Andersson N Socio-economic status and HIV and AIDS stigma in Tanzania. Mbaraka A, Mitchell S, Cockcroft A, Andersson N Choice disability and HIV prevention knowledge, attitudes and practices in Botswana. Ho-Foster A, Andersson N, Cockcroft A, Masisi M, Laetsang D, Kgakole L What has happened to multiple sexual partnerships in Swaziland between 2002 and 2008? Cockcroft A, Andersson N, Ho-Foster A, Marokoane N, Mziyako B

  13. ADAPT publications in peer reviewed journals Ho-Foster A, Laetsang D, Masisi M, Anderson M, Tlhoiwe D, Cockcroft A, Andersson N.. Gender-specific patterns of multiple concurrent sexual partnerships: a national cross sectional survey in Botswana. AIDS Care 2010: 1-6 (doi: 10.1080/09540121003758598) Cockcroft A, Lengwe KundaJ, Kgakole L, MasisiM, Laetsang D, Ho-Foster A, Marokoane N, Andersson N. Community views of inter-generational sex: findings from focus groups in Botswana, Namibia and Swaziland. Psychology, Health and Medicine 2010 (in press) Amuri B, Mitchell S, Cockcroft A, Andersson N. Socio-economic status and HIV and AIDS stigma in Tanzania. AIDS Care 2010 (in press) Cockcroft A, Andersson N, Ho-Foster A, Marokoane N, Mziyako B What happened to multiple sexual partnerships in Swaziland? Analysis of five linked national surveys between 2002 and 2008. AIDS Care 2010: 1-6 (doi: 10.1080/09540121.2010.482123)

  14. Second course • Nominations from SADC NAAs • 1st three week block 28 Jan–15 Feb 2013 • 20 participants: • 4 Botswana, 1 Mauritius, 3 Namibia, 4 Swaziland, 2 Tanzania, 2 Zambia, 4 Zimbabwe • Epidemiology and statistics relevant to RCTs • Support to develop fundable HIV prevention research proposals

  15. Research topics • Multiple concurrent partnerships in young women • HIV risks in female sex workers • Sexual behaviour after male circumcision • Sexual behaviour among college students • Condition cash transfers and HIV trial • HIV infection through breastfeeding • Role of older people in youth HIV prevention

  16. Systematic review module • 16-20 July 2012 • School of Nursing and Public Health, UNAM • 10 participants – mostly SNPH faculty

  17. Systematic review module • Methods of analysis of RCTs • RCTs and non-experimental study designs • Elements of SR and meta-analysis • data extraction • dealing with heterogeneity between studies • interpretation of forest plots • assessment of quality of studies and SRs

  18. Systematic review module • Practical experience • navigating Cochrane website • searching literature • using Revman software to conduct meta analysis

  19. Systematic review module The Dean of the SNPH presented certificates on the final day

  20. Capacity building for Botswana parliamentarians Participants in the first session – November 2011

  21. Botswana parliamentarians Evidence-based decision making Two training sessions • 31 October/1 November 2011 • 12 and 14 November 2012 Logistic organisation by NACA Attended by • 36 of 61 MPs • Including 7 ministers

  22. Laboratory skills training National Institute for Communicable Diseases, Johannesburg, S Africa • Two SADC one-week courses: • HIV serology on dried blood spots • New techniques for estimating HIV incidence Participants: >With basic laboratory skills

  23. ADAPT training

  24. Challenges • Retaining trained individuals in system • Organisations not allowing time out for higher qualifications • SADC bureaucracy (laboratory courses) • Obtaining funding for African led research

  25. By end of ADAPT • Network of trained HIV researchers in SADC countries • Improved institutional capacities for research • Several fundable proposals for RCTs led by African researchers • Better informed and equipped decision makers

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