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BIOLOGICAL SAFETY

BIOLOGICAL SAFETY. Safety for people, animals, plants…. Session 7 Laboratory Safety Training. WHY IS BIOLOGICAL SAFETY IMPORTANT?. Campus – have wide use of biologicals 9 of 12 colleges/schools use biohazardous agents Research, Teaching, Outreach Bloodborne Pathogens

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BIOLOGICAL SAFETY

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  1. BIOLOGICAL SAFETY Safety for people, animals, plants… Session 7 Laboratory Safety Training

  2. WHY IS BIOLOGICAL SAFETY IMPORTANT? • Campus – have wide use of biologicals • 9 of 12 colleges/schools use biohazardous agents • Research, Teaching, Outreach • Bloodborne Pathogens • Prevent disease in personnel • Prevent release of organisms/agents into environment

  3. What are BioHazardous Materials? • Any biological material capable of causing harm to humans, animals, plants • BioHazardous Agents – Pathogens that can replicate & cause disease • Toxins – Microbial poisons

  4. BIOHAZARDOUS AGENTS • Bacteria (Streptococcus pyogenes) • Fungi (Candida, Histoplasma) • Viruses (HIV, HBV) • Prions (CJD) • Parasites (Giardia, Strongyloides)

  5. TOXINS • Exotoxins – produced by bacteria Clostridium botulinum - food poisoning, one of most deadly Clostridium tetanii - tetanus Corynebacterium diphtheriae - diptheria Bioterrorism use • Endotoxins – released from cell wall when bacteria disintegrates

  6. Read the BIOLOGICAL SAFETY MANUAL

  7. INSTITUTIONAL BIOSAFETYCOMMITTEE (IBC) • Mandated by National Institutes of Heath (NIH) • Must review and approve all usage of Risk Group 2 or higher agents • Must review and approve rDNA usage, formation of transgenic animals, experiments involving human gene therapy • Applies to Faculty, Community, Laboratory Staff, Continuing Members, etc.

  8. CLASSIFICATION SYSTEM FOR BIOHAZARDOUS MATERIALS

  9. Responsible Faculty or PI • Files a BUA – Biological Usage Authorization • Trains all personnel • Establishes emergency procedures • Reports incidents with biologicals • Posts biohazard warning signs • Cooperates with Biological Safety Officer during inspection visits

  10. BIOLOGICAL USAGE AUTHORIZATION“BUA” • Describes the PI’s Research Project • Required when biohazardous material is stored, used, or transported • Good for 3 years • Can be amended

  11. Cannot be brought on campus Reference material can be kept in inactive state (frozen or lyophilized) List of all references must be given to IBC Appendix H Mycobacterium tuberculosis Hantavirus Foreign Animal Pathogens HIV 1 & 2 FORBIDDEN AGENTS

  12. CDC SELECT AGENTS • Cannot be brought on campus without prior approval & registration • Must be registered with University BioSafety Officer • Required under: • U.S. BioTerrorism Prevention Act • USA Patriot Act (USAPA) • TAMUS Regulations & TAMU Rules

  13. THE BIOSAFETY INSPECTION ! • PPE • Training • Signage • Adherence to Protocol • Technique • Physical Facility • General Safety

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